Entity Details

Primary name HDAC2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70288
EntryNameHDAC2_MOUSE
FullNameHistone deacetylase 2
TaxID10090
Evidenceevidence at protein level
Length488
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesHdac2

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006325 chromatin organization
GO:0006476 protein deacetylation
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009913 epidermal cell differentiation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0016575 histone deacetylation
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0017053 transcription repressor complex
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0031072 heat shock protein binding
GO:0031490 chromatin DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032732 positive regulation of interleukin-1 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0033558 protein deacetylase activity
GO:0034739 histone deacetylase activity (H4-K16 specific)
GO:0035098 ESC/E(Z) complex
GO:0035851 Krueppel-associated box domain binding
GO:0035984 cellular response to trichostatin A
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042733 embryonic digit morphogenesis
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051059 NF-kappaB binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051896 regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060297 regulation of sarcomere organization
GO:0060789 hair follicle placode formation
GO:0061000 negative regulation of dendritic spine development
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070301 cellular response to hydrogen peroxide
GO:0070734 histone H3-K27 methylation
GO:0070829 heterochromatin maintenance
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090311 regulation of protein deacetylation
GO:0090571 RNA polymerase II transcription repressor complex
GO:1902437 positive regulation of male mating behavior
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1990841 promoter-specific chromatin binding
GO:2000273 positive regulation of signaling receptor activity
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR003084 Histone deacetylaseFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
HDAC2_MOUSEAN32A_MOUSEMINT17557114 details
HDAC2_MOUSEGFI1B_MOUSEBioGRID, UniProt17707228 details
HDAC2_MOUSEZN431_MOUSEBioGRID, UniProt21177534 details
HDAC2_MOUSESIX3_MOUSEDIP17666527 details
HDAC2_MOUSECIR1_HUMANBioGRID9874765 details
HDAC2_MOUSETHB_HUMANBioGRID10508171 details
HDAC2_MOUSETHA_HUMANBioGRID10508171 details
HDAC2_MOUSECTBP1_MOUSEBioGRID20211142 details
HDAC2_MOUSEHDAC9_MOUSEBioGRID20211142 details
HDAC2_MOUSEPDX1_MOUSEBioGRID15496408 details
HDAC2_MOUSECRY1_MOUSEBioGRID15226430 details
HDAC2_MOUSEDDX20_MOUSEBioGRID12007404 details
HDAC2_MOUSEH4_MOUSEBioGRID22441348 details
HDAC2_MOUSESAP30_MOUSEIntAct9702189 details
HDAC2_MOUSETAL1_MOUSEMINT16407974 details
HDAC2_MOUSESIN3A_MOUSEBioGRID, DIP, IntAct, MINT15696166 16109738 18454139 19424149 20404188 24240174 details
HDAC2_MOUSEARI1A_MOUSEBioGRID, MINT17255939 details
HDAC2_MOUSESOX2_MOUSEBioGRID, IntAct19139101 21103394 details
HDAC2_MOUSENANOG_MOUSEBioGRID, IntAct17093407 18454139 23395962 details
HDAC2_MOUSEPO5F1_MOUSEBioGRID, IntAct17093407 18454139 20362541 details
HDAC2_MOUSEPRDM1_HUMANMINT22555612 details
HDAC2_MOUSEMTA2_MOUSEBioGRID, DIP, MINT15920471 18454139 19424149 20404188 24240174 details
HDAC2_MOUSEFOXP3_MOUSEBioGRID, IntAct22922362 26365427 details
HDAC2_MOUSERCOR2_MOUSEDIP19424149 details
HDAC2_MOUSEHDAC1_MOUSEBioGRID, DIP16109738 19424149 20404188 22297846 details
HDAC2_MOUSEKDM1A_MOUSEBioGRID, DIP20404188 22297846 26206133 details
HDAC2_MOUSESMCA4_MOUSEDIP20596014 details
HDAC2_MOUSEPARP1_MOUSEDIP20596014 details
HDAC2_MOUSETYY1_MOUSEBioGRID17220375 details
HDAC2_MOUSETF7L2_MOUSEBioGRID19503085 details
HDAC2_MOUSEMBD3_MOUSEBioGRID18454139 details
HDAC2_MOUSERBBP7_MOUSEBioGRID18454139 details
HDAC2_MOUSESP3_MOUSEBioGRID16109738 details
HDAC2_MOUSEPML_MOUSEBioGRID18454139 details
HDAC2_MOUSEGATA1_MOUSEBioGRID15920471 details
HDAC2_MOUSEIRS1_MOUSEBioGRID15522123 details
HDAC2_MOUSERING2_MOUSEBioGRID17296600 22496869 details
HDAC2_MOUSEFOSB_MOUSEBioGRID21258411 details
HDAC2_MOUSESPI1_MOUSEBioGRID21518930 details
HDAC2_MOUSEAPEX1_MOUSEBioGRID22441348 details
HDAC2_MOUSEJDP2_MOUSEBioGRID22989952 details
HDAC2_MOUSEATF3_MOUSEBioGRID22989952 details
HDAC2_MOUSESMYD1_MOUSEBioGRID11923873 details
HDAC2_MOUSETET2_MOUSEBioGRID21490601 details
HDAC2_MOUSELMBL2_MOUSEBioGRID22770845 details
HDAC2_MOUSEKLF5_MOUSEBioGRID18983969 details
HDAC2_MOUSELCLT1_MOUSEBioGRID26604221 details
HDAC2_MOUSECAF1A_MOUSEBioGRID26365490 details
HDAC2_MOUSESNAI1_HUMANBioGRID28892081 details
HDAC2_MOUSEOGG1_MOUSEBioGRID22057269 details