Entity Details

Primary name NOS3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70313
EntryNameNOS3_MOUSE
FullNameNitric oxide synthase, endothelial
TaxID10090
Evidenceevidence at protein level
Length1202
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesNos3

GO terms

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GOName
GO:0001542 ovulation from ovarian follicle
GO:0001701 in utero embryonic development
GO:0003180 aortic valve morphogenesis
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006809 nitric oxide biosynthetic process
GO:0008013 beta-catenin binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0030324 lung development
GO:0031284 positive regulation of guanylate cyclase activity
GO:0045296 cadherin binding
GO:0045776 negative regulation of blood pressure
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048873 homeostasis of number of cells within a tissue
GO:0050998 nitric-oxide synthase binding
GO:0051879 Hsp90 protein binding
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0003184 pulmonary valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003785 actin monomer binding
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0006527 arginine catabolic process
GO:0007165 signal transduction
GO:0007263 nitric oxide mediated signal transduction
GO:0009725 response to hormone
GO:0014740 negative regulation of muscle hyperplasia
GO:0014806 smooth muscle hyperplasia
GO:0019430 removal of superoxide radicals
GO:0020037 heme binding
GO:0032355 response to estradiol
GO:0034617 tetrahydrobiopterin binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045177 apical part of cell
GO:0050660 flavin adenine dinucleotide binding
GO:0051346 negative regulation of hydrolase activity
GO:0051926 negative regulation of calcium ion transport
GO:0097746 blood vessel diameter maintenance
GO:0001525 angiogenesis
GO:0001974 blood vessel remodeling
GO:0002028 regulation of sodium ion transport
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0004517 nitric-oxide synthase activity
GO:0005516 calmodulin binding
GO:0005829 cytosol
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0046872 metal ion binding
GO:0050661 NADP binding
GO:0070168 negative regulation of biomineral tissue development
GO:0097110 scaffold protein binding
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0012506 vesicle membrane
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0031644 regulation of nervous system process
GO:0032496 response to lipopolysaccharide
GO:0034618 arginine binding
GO:0042383 sarcolemma
GO:0043065 positive regulation of apoptotic process
GO:0043267 negative regulation of potassium ion transport
GO:0043542 endothelial cell migration
GO:0060412 ventricular septum morphogenesis
GO:0071260 cellular response to mechanical stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Membrane

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR004030 Nitric oxide synthase, N-terminalDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR012144 Nitric-oxide synthase, eukaryoteFamilyFamily
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR036119 Nitric oxide synthase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Interactions

4 interactions