Entity Details

Primary name ROCK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70335
EntryNameROCK1_MOUSE
FullNameRho-associated protein kinase 1
TaxID10090
Evidenceevidence at protein level
Length1354
SequenceStatuscomplete
DateCreated2004-05-24
DateModified2021-06-02

Ontological Relatives

GenesRock1

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0000281 mitotic cytokinesis
GO:0001726 ruffle
GO:0001837 epithelial to mesenchymal transition
GO:0003383 apical constriction
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007010 cytoskeleton organization
GO:0007159 leukocyte cell-cell adhesion
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007266 Rho protein signal transduction
GO:0010494 cytoplasmic stress granule
GO:0010508 positive regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0022614 membrane to membrane docking
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030334 regulation of cell migration
GO:0030866 cortical actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0031267 small GTPase binding
GO:0032059 bleb
GO:0032060 bleb assembly
GO:0032091 negative regulation of protein binding
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0042326 negative regulation of phosphorylation
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045616 regulation of keratinocyte differentiation
GO:0045664 regulation of neuron differentiation
GO:0046872 metal ion binding
GO:0048598 embryonic morphogenesis
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051451 myoblast migration
GO:0051894 positive regulation of focal adhesion assembly
GO:0061157 mRNA destabilization
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071559 response to transforming growth factor beta
GO:0072518 Rho-dependent protein serine/threonine kinase activity
GO:0072659 protein localization to plasma membrane
GO:0090521 glomerular visceral epithelial cell migration
GO:0097746 blood vessel diameter maintenance
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110061 regulation of angiotensin-activated signaling pathway
GO:0140058 neuron projection arborization
GO:1900223 positive regulation of amyloid-beta clearance
GO:1900242 regulation of synaptic vesicle endocytosis
GO:1901888 regulation of cell junction assembly
GO:1902430 negative regulation of amyloid-beta formation
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1905205 positive regulation of connective tissue replacement
GO:1990776 response to angiotensin

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011072 HR1 rho-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015008 ROCK, Rho binding domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020684 Rho-associated protein kinase 1/2FamilyFamily
IPR037310 Rho-associated protein kinase 1, HR1DomainDomain

Diseases

Show/Hide Table