Entity Details

Primary name SMAD1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70340
EntryNameSMAD1_MOUSE
FullNameMothers against decapentaplegic homolog 1
TaxID10090
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesSmad1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001710 mesodermal cell fate commitment
GO:0002051 osteoblast fate commitment
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007276 gamete generation
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0009880 embryonic pattern specification
GO:0010628 positive regulation of gene expression
GO:0017151 DEAD/H-box RNA helicase binding
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030509 BMP signaling pathway
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0032991 protein-containing complex
GO:0042493 response to drug
GO:0042592 homeostatic process
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0045597 positive regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0051148 negative regulation of muscle cell differentiation
GO:0051216 cartilage development
GO:0060038 cardiac muscle cell proliferation
GO:0060348 bone development
GO:0060395 SMAD protein signal transduction
GO:0061036 positive regulation of cartilage development
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070878 primary miRNA binding
GO:0071144 heteromeric SMAD protein complex
GO:0071407 cellular response to organic cyclic compound
GO:0071773 cellular response to BMP stimulus
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903672 positive regulation of sprouting angiogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
SMAD1_MOUSEPAR3_MOUSEMINT12650946 details
SMAD1_MOUSEERBIN_MOUSEMINT12650946 details
SMAD1_MOUSEDVL1_MOUSEMINT12650946 details
SMAD1_MOUSEM3K7_MOUSEMINT19536134 details
SMAD1_MOUSEHXA13_MOUSEBioGRID, IntAct16087734 details
SMAD1_MOUSEHXD13_MOUSEBioGRID, IntAct16087734 details
SMAD1_MOUSESMUF1_MOUSEBioGRID12370310 details
SMAD1_MOUSEZNF8_MOUSEBioGRID12370310 details
SMAD1_MOUSEZEB2_MOUSEBioGRID20211142 details
SMAD1_MOUSEGATA4_MOUSEBioGRID14662776 details
SMAD1_MOUSEKAT2B_MOUSEBioGRID14500836 details
SMAD1_MOUSEMECOM_MOUSEBioGRID15849193 details
SMAD1_MOUSESUV92_MOUSEBioGRID15107829 details
SMAD1_MOUSEARI1A_MOUSEBioGRID, MINT17255939 details
SMAD1_MOUSEKGP1_MOUSEMINT19424179 details
SMAD1_MOUSEUCHL3_HUMANMINT21453705 details
SMAD1_MOUSEUCHL3_MOUSEMINT21453705 details
SMAD1_MOUSESMRD3_MOUSEBioGRID15525990 details
SMAD1_MOUSEERCC3_MOUSEBioGRID16101586 details
SMAD1_MOUSEBACH1_MOUSEBioGRID16101586 details
SMAD1_MOUSEKLF10_MOUSEBioGRID16101586 details
SMAD1_MOUSEPRS6A_MOUSEBioGRID16101586 details
SMAD1_MOUSESMAD9_MOUSEBioGRID16101586 details
SMAD1_MOUSECXB6_MOUSEBioGRID16101586 details
SMAD1_MOUSEMXI1_MOUSEBioGRID16101586 details
SMAD1_MOUSEMYOD1_MOUSEBioGRID11711431 details
SMAD1_MOUSERUNX2_MOUSEBioGRID12738770 details
SMAD1_MOUSEBTG2_MOUSEBioGRID15542835 details
SMAD1_MOUSEPEX6_MOUSEBioGRID14651998 details
SMAD1_MOUSE4ET_MOUSEBioGRID14651998 details
SMAD1_MOUSEZMYM2_MOUSEBioGRID14651998 details
SMAD1_MOUSECO3A1_MOUSEBioGRID14559231 details
SMAD1_MOUSECO5A1_MOUSEBioGRID14559231 details
SMAD1_MOUSEPRD16_MOUSEBioGRID17467076 details
SMAD1_MOUSESMUF2_MOUSEBioGRID20956305 23969857 details