Entity Details

Primary name CASP4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70343
EntryNameCASP4_MOUSE
FullNameCaspase-4
TaxID10090
Evidenceevidence at protein level
Length373
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCasp4

GO terms

Show/Hide Table
GOName
GO:0004197 cysteine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007015 actin filament organization
GO:0016540 protein autoprocessing
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032991 protein-containing complex
GO:0035234 ectopic germ cell programmed cell death
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045087 innate immune response
GO:0050700 CARD domain binding
GO:0050727 regulation of inflammatory response
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070269 pyroptosis
GO:0072557 IPAF inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097110 scaffold protein binding
GO:0097169 AIM2 inflammasome complex
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1904646 cellular response to amyloid-beta

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Inflammasome
Mitochondrion
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CASP4_MOUSEGSDMD_HUMANDIP26375003 details
CASP4_MOUSEGSDMD_MOUSEDIP26375259 details