Entity Details

Primary name NAC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70414
EntryNameNAC1_MOUSE
FullNameSodium/calcium exchanger 1
TaxID10090
Evidenceevidence at protein level
Length970
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesSlc8a1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001892 embryonic placenta development
GO:0002026 regulation of the force of heart contraction
GO:0002027 regulation of heart rate
GO:0002028 regulation of sodium ion transport
GO:0003007 heart morphogenesis
GO:0005432 calcium:sodium antiporter activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006883 cellular sodium ion homeostasis
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008092 cytoskeletal protein binding
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0010763 positive regulation of fibroblast migration
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014069 postsynaptic density
GO:0014704 intercalated disc
GO:0014829 vascular associated smooth muscle contraction
GO:0015491 cation:cation antiporter activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030001 metal ion transport
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030424 axon
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030506 ankyrin binding
GO:0031226 intrinsic component of plasma membrane
GO:0033198 response to ATP
GO:0034614 cellular response to reactive oxygen species
GO:0035050 embryonic heart tube development
GO:0035725 sodium ion transmembrane transport
GO:0035994 response to muscle stretch
GO:0036376 sodium ion export across plasma membrane
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043679 axon terminus
GO:0044325 transmembrane transporter binding
GO:0044557 relaxation of smooth muscle
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051924 regulation of calcium ion transport
GO:0055013 cardiac muscle cell development
GO:0055074 calcium ion homeostasis
GO:0060048 cardiac muscle contraction
GO:0060402 calcium ion transport into cytosol
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0071313 cellular response to caffeine
GO:0071320 cellular response to cAMP
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071944 cell periphery
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0098703 calcium ion import across plasma membrane
GO:0098719 sodium ion import across plasma membrane
GO:0098735 positive regulation of the force of heart contraction
GO:0098794 postsynapse
GO:0099055 integral component of postsynaptic membrane
GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential
GO:1901660 calcium ion export
GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001623 DnaJ domainDomainDomain
IPR002987 Sodium/calcium exchanger, isoform 1FamilyFamily
IPR003644 Na-Ca exchanger/integrin-beta4DomainDomain
IPR004836 Sodium/calcium exchanger proteinFamilyFamily
IPR004837 Sodium/calcium exchanger membrane regionDomainDomain
IPR032452 Sodium/calcium exchanger domain, C-terminal extensionDomainDomain
IPR038081 CalX-like domain superfamilyFamilyHomologous superfamily

Diseases

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