Entity Details

Primary name ERBB2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70424
EntryNameERBB2_MOUSE
FullNameReceptor tyrosine-protein kinase erbB-2
TaxID10090
Evidenceevidence at protein level
Length1256
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesErbb2

GO terms

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GOName
GO:0001042 RNA polymerase I core binding
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007528 neuromuscular junction development
GO:0008022 protein C-terminus binding
GO:0008045 motor neuron axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0010001 glial cell differentiation
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0019903 protein phosphatase binding
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032886 regulation of microtubule-based process
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033674 positive regulation of kinase activity
GO:0035556 intracellular signal transduction
GO:0038143 ERBB3:ERBB2 complex
GO:0042060 wound healing
GO:0042552 myelination
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043125 ErbB-3 class receptor binding
GO:0043209 myelin sheath
GO:0043219 lateral loop
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043547 positive regulation of GTPase activity
GO:0044849 estrous cycle
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
GO:0045727 positive regulation of translation
GO:0045785 positive regulation of cell adhesion
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0048485 sympathetic nervous system development
GO:0048678 response to axon injury
GO:0048709 oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051879 Hsp90 protein binding
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0090314 positive regulation of protein targeting to membrane

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome
Nucleus

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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