Entity Details

Primary name CASP3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP70677
EntryNameCASP3_MOUSE
FullNameCaspase-3
TaxID10090
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCasp3

GO terms

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GOName
GO:0001554 luteolysis
GO:0001666 response to hypoxia
GO:0001782 B cell homeostasis
GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005123 death receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007413 axonal fasciculation
GO:0007507 heart development
GO:0007605 sensory perception of sound
GO:0007611 learning or memory
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0009411 response to UV
GO:0009611 response to wounding
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010165 response to X-ray
GO:0016005 phospholipase A2 activator activity
GO:0016485 protein processing
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030218 erythrocyte differentiation
GO:0030889 negative regulation of B cell proliferation
GO:0031264 death-inducing signaling complex
GO:0031647 regulation of protein stability
GO:0032025 response to cobalt ion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0034349 glial cell apoptotic process
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042060 wound healing
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043025 neuronal cell body
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043525 positive regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045165 cell fate commitment
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 negative regulation of cell cycle
GO:0046007 negative regulation of activated T cell proliferation
GO:0046677 response to antibiotic
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051146 striated muscle cell differentiation
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0061713 anterior neural tube closure
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310 cellular response to organic substance
GO:0071887 leukocyte apoptotic process
GO:0072734 cellular response to staurosporine
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902004 positive regulation of amyloid-beta formation

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR015471 Caspase-3/7FamilyFamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site

Diseases

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