Entity Details

Primary name OTX2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP80206
EntryNameOTX2_MOUSE
FullNameHomeobox protein OTX2
TaxID10090
Evidenceevidence at protein level
Length289
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001708 cell fate specification
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007492 endoderm development
GO:0009887 animal organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0021978 telencephalon regionalization
GO:0022037 metencephalon development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030426 growth cone
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0032525 somite rostral/caudal axis specification
GO:0032991 protein-containing complex
GO:0040019 positive regulation of embryonic development
GO:0042472 inner ear morphogenesis
GO:0042706 eye photoreceptor cell fate commitment
GO:0045165 cell fate commitment
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048382 mesendoderm development
GO:0048663 neuron fate commitment
GO:0048664 neuron fate determination
GO:0048709 oligodendrocyte differentiation
GO:0048852 diencephalon morphogenesis
GO:0048856 anatomical structure development
GO:0065003 protein-containing complex assembly
GO:0071542 dopaminergic neuron differentiation
GO:0090009 primitive streak formation
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000543 positive regulation of gastrulation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR003022 Transcription factor Otx2FamilyFamily
IPR003025 Transcription factor OtxFamilyFamily
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR013851 Transcription factor Otx, C-terminalDomainDomain
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
OTX2_MOUSEDMBX1_MOUSEMINT15890343 details
OTX2_MOUSEOTX2_MOUSEMINT15890343 details