Entity Details

Primary name IRS2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP81122
EntryNameIRS2_MOUSE
FullNameInsulin receptor substrate 2
TaxID10090
Evidenceevidence at protein level
Length1321
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesIrs2

GO terms

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GOName
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002903 negative regulation of B cell apoptotic process
GO:0005158 insulin receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007420 brain development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010907 positive regulation of glucose metabolic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0030890 positive regulation of B cell proliferation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032024 positive regulation of insulin secretion
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033673 negative regulation of kinase activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0071333 cellular response to glucose stimulus
GO:0071889 14-3-3 protein binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR002404 IRS-type PTB domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR039011 Insulin receptor substrateFamilyFamily

Diseases

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