Entity Details

Primary name EP300_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionB2RWS6
EntryNameEP300_MOUSE
FullNameHistone acetyltransferase p300
TaxID10090
Evidenceevidence at protein level
Length2412
SequenceStatuscomplete
DateCreated2011-05-31
DateModified2021-06-02

Ontological Relatives

GenesEp300

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000123 histone acetyltransferase complex
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001666 response to hypoxia
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001966 thigmotaxis
GO:0002039 p53 binding
GO:0002209 behavioral defense response
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003713 transcription coactivator activity
GO:0003823 antigen binding
GO:0004402 histone acetyltransferase activity
GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006110 regulation of glycolytic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006915 apoptotic process
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0007049 cell cycle
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0009749 response to glucose
GO:0009887 animal organ morphogenesis
GO:0010484 H3 histone acetyltransferase activity
GO:0010485 H4 histone acetyltransferase activity
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0010742 macrophage derived foam cell differentiation
GO:0010821 regulation of mitochondrion organization
GO:0010942 positive regulation of cell death
GO:0010976 positive regulation of neuron projection development
GO:0014737 positive regulation of muscle atrophy
GO:0016407 acetyltransferase activity
GO:0016573 histone acetylation
GO:0016746 acyltransferase activity
GO:0018076 N-terminal peptidyl-lysine acetylation
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0030220 platelet formation
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031324 negative regulation of cellular metabolic process
GO:0031325 positive regulation of cellular metabolic process
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031490 chromatin DNA binding
GO:0031648 protein destabilization
GO:0032092 positive regulation of protein binding
GO:0032967 positive regulation of collagen biosynthetic process
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0034644 cellular response to UV
GO:0035066 positive regulation of histone acetylation
GO:0035259 glucocorticoid receptor binding
GO:0035264 multicellular organism growth
GO:0035855 megakaryocyte development
GO:0036268 swimming
GO:0042307 positive regulation of protein import into nucleus
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043425 bHLH transcription factor binding
GO:0043491 protein kinase B signaling
GO:0043627 response to estrogen
GO:0043923 positive regulation by host of viral transcription
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0043969 histone H2B acetylation
GO:0044877 protein-containing complex binding
GO:0045444 fat cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0045727 positive regulation of translation
GO:0045773 positive regulation of axon extension
GO:0045793 positive regulation of cell size
GO:0045815 positive regulation of gene expression, epigenetic
GO:0045862 positive regulation of proteolysis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0050681 androgen receptor binding
GO:0050714 positive regulation of protein secretion
GO:0050821 protein stabilization
GO:0051019 mitogen-activated protein kinase binding
GO:0051059 NF-kappaB binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051216 cartilage development
GO:0051592 response to calcium ion
GO:0060177 regulation of angiotensin metabolic process
GO:0060298 positive regulation of sarcomere organization
GO:0060325 face morphogenesis
GO:0060548 negative regulation of cell death
GO:0060765 regulation of androgen receptor signaling pathway
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0061733 peptide-lysine-N-acetyltransferase activity
GO:0061920 protein propionyltransferase activity
GO:0061921 peptidyl-lysine propionylation
GO:0065004 protein-DNA complex assembly
GO:0071548 response to dexamethasone
GO:0090043 regulation of tubulin deacetylation
GO:0097157 pre-mRNA intronic binding
GO:0097677 STAT family protein binding
GO:0106226 peptide 2-hydroxyisobutyryltransferase activity
GO:0120301 histone lactyltransferase activity
GO:0140065 peptide butyryltransferase activity
GO:0140066 peptidyl-lysine crotonylation
GO:0140067 peptidyl-lysine butyrylation
GO:0140068 histone crotonyltransferase activity
GO:0140069 histone butyryltransferase activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901985 positive regulation of protein acetylation
GO:1905636 positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1990405 protein antigen binding
GO:1990841 promoter-specific chromatin binding
GO:2000629 negative regulation of miRNA metabolic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000197 Zinc finger, TAZ-typeDomainDomain
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR001487 BromodomainDomainDomain
IPR003101 Coactivator CBP, KIX domainDomainDomain
IPR009110 Nuclear receptor coactivator, interlockingFamilyHomologous superfamily
IPR010303 CREB-binding protein/p300, atypical RING domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013178 Histone acetyltransferase Rtt109/CBPFamilyFamily
IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlockingDomainDomain
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR031162 CBP/p300-type histone acetyltransferase domainDomainDomain
IPR035898 TAZ domain superfamilyFamilyHomologous superfamily
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR036529 Coactivator CBP, KIX domain superfamilyFamilyHomologous superfamily
IPR037073 Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamilyFamilyHomologous superfamily
IPR038547 CBP/p300, atypical RING domain superfamilyFamilyHomologous superfamily
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
EP300_MOUSEP53_MOUSEBioGRID, DIP, I2D, IntAct10706102 14555661 21057544 22666487 25117711 9194565 details
EP300_MOUSETF65_MOUSEBioGRID, DIP12672795 20211142 23999430 24019758 details
EP300_MOUSEBMAL1_MOUSEDIP25961797 details
EP300_MOUSEBMAL2_MOUSEDIP25961797 details
EP300_MOUSETLE6_MOUSEBioGRID, IntAct20211142 details
EP300_MOUSENCOA1_MOUSEBioGRID8855229 details
EP300_MOUSENUPR1_MOUSEBioGRID19723804 details
EP300_MOUSEKAT2B_MOUSEBioGRID20211142 9659901 9742083 details
EP300_MOUSEGATA4_MOUSEBioGRID11481322 details
EP300_MOUSECDK9_HUMANBioGRID20081228 details
EP300_MOUSEMECP2_MOUSEBioGRID22677942 details
EP300_MOUSEH2A3_MOUSEBioGRID16704373 details
EP300_MOUSEFOXO3_HUMANBioGRID11896584 details
EP300_MOUSEKAT2A_MOUSEBioGRID9742083 details
EP300_MOUSECREB1_MOUSEBioGRID17525731 details
EP300_MOUSEP85A_MOUSEBioGRID, I2D21057544 details
EP300_MOUSESNIP1_MOUSEUniProt15378006 details
EP300_MOUSESTAT6_MOUSEIntAct26365427 details
EP300_MOUSETYY1_MOUSEBioGRID17220375 details
EP300_MOUSEEPC1_MOUSEBioGRID19359245 details
EP300_MOUSEPITX2_MOUSEBioGRID12464179 details
EP300_MOUSECEBPB_MOUSEBioGRID15878863 details
EP300_MOUSEMYOD1_MOUSEBioGRID14749395 9659901 details
EP300_MOUSESIR1_MOUSEBioGRID21454709 details
EP300_MOUSECCNT1_HUMANBioGRID20081228 details
EP300_MOUSEGATA4_HUMANBioGRID20081228 details
EP300_MOUSEACTB_HUMANBioGRID20081228 details
EP300_MOUSEEP300_HUMANBioGRID20081228 details
EP300_MOUSERPB1_HUMANBioGRID20081228 details
EP300_MOUSEZBT7B_MOUSEBioGRID20810990 details
EP300_MOUSENR1H4_MOUSEBioGRID19883617 details
EP300_MOUSEFOXO3_MOUSEBioGRID18268343 22094330 details
EP300_MOUSEATF2_MOUSEBioGRID10327051 details
EP300_MOUSEFOXP3_MOUSEBioGRID22579476 details
EP300_MOUSECEBPA_MOUSEBioGRID22086955 details
EP300_MOUSEUSF1_MOUSEBioGRID21680747 details
EP300_MOUSECHD4_MOUSEBioGRID15189737 details
EP300_MOUSEHTF4_MOUSEBioGRID15189737 32325033 details
EP300_MOUSEBC11B_MOUSEBioGRID16809611 details
EP300_MOUSESPI1_MOUSEBioGRID16702405 17562868 details
EP300_MOUSEHIF1A_MOUSEBioGRID18268343 details
EP300_MOUSEMYCD_MOUSEBioGRID15601857 details
EP300_MOUSERARA_MOUSEBioGRID21722948 details
EP300_MOUSERARB_MOUSEBioGRID21722948 details
EP300_MOUSERARG_MOUSEBioGRID21722948 details
EP300_MOUSEETV4_MOUSEBioGRID14976201 details
EP300_MOUSESRC_MOUSEBioGRID26695438 details
EP300_MOUSEESR1_MOUSEBioGRID24586743 details
EP300_MOUSECNTN2_MOUSEBioGRID24586743 details