Entity Details

Primary name WNK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP83741
EntryNameWNK1_MOUSE
FullNameSerine/threonine-protein kinase WNK1
TaxID10090
Evidenceevidence at protein level
Length2377
SequenceStatuscomplete
DateCreated2004-04-26
DateModified2021-06-02

Ontological Relatives

GenesWnk1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0002028 regulation of sodium ion transport
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0010766 negative regulation of sodium ion transport
GO:0010820 positive regulation of T cell chemotaxis
GO:0010923 negative regulation of phosphatase activity
GO:0016020 membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019869 chloride channel inhibitor activity
GO:0019870 potassium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0030295 protein kinase activator activity
GO:0033633 negative regulation of cell-cell adhesion mediated by integrin
GO:0033673 negative regulation of kinase activity
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034260 negative regulation of GTPase activity
GO:0035556 intracellular signal transduction
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway
GO:0046777 protein autophosphorylation
GO:0050794 regulation of cellular process
GO:0050801 ion homeostasis
GO:0050852 T cell receptor signaling pathway
GO:0071277 cellular response to calcium ion
GO:0090188 negative regulation of pancreatic juice secretion
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097022 lymphocyte migration into lymph node
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903288 positive regulation of potassium ion import across plasma membrane
GO:1904062 regulation of cation transmembrane transport
GO:1990869 cellular response to chemokine
GO:2000651 positive regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
WNK1_MOUSEOTUD4_HUMANBioGRID31138677 details
WNK1_MOUSEITB2_MOUSEBioGRID30333137 details