Entity Details

Primary name MCL1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP97287
EntryNameMCL1_MOUSE
FullNameInduced myeloid leukemia cell differentiation protein Mcl-1 homolog
TaxID10090
Evidenceevidence at protein level
Length331
SequenceStatuscomplete
DateCreated2005-12-06
DateModified2021-06-02

Ontological Relatives

GenesMcl1

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0007275 multicellular organism development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0010507 negative regulation of autophagy
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030154 cell differentiation
GO:0034097 response to cytokine
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0051400 BH domain binding
GO:0051434 BH3 domain binding
GO:0097136 Bcl-2 family protein complex
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001020 regulation of response to DNA damage stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR013281 Apoptosis regulator, Mcl-1FamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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