Entity Details

Primary name PRKDC_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP97313
EntryNamePRKDC_MOUSE
FullNameDNA-dependent protein kinase catalytic subunit
TaxID10090
Evidenceevidence at protein level
Length4128
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesPrkdc

GO terms

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GOName
GO:0000460 maturation of 5.8S rRNA
GO:0000723 telomere maintenance
GO:0001756 somitogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002218 activation of innate immune response
GO:0002326 B cell lineage commitment
GO:0002328 pro-B cell differentiation
GO:0002360 T cell lineage commitment
GO:0002638 negative regulation of immunoglobulin production
GO:0002684 positive regulation of immune system process
GO:0003690 double-stranded DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004677 DNA-dependent protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212 response to ionizing radiation
GO:0010332 response to gamma radiation
GO:0014823 response to activity
GO:0016233 telomere capping
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030098 lymphocyte differentiation
GO:0031648 protein destabilization
GO:0032040 small-subunit processome
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0033152 immunoglobulin V(D)J recombination
GO:0033153 T cell receptor V(D)J recombination
GO:0034462 small-subunit processome assembly
GO:0034511 U3 snoRNA binding
GO:0035234 ectopic germ cell programmed cell death
GO:0042752 regulation of circadian rhythm
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045727 positive regulation of translation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048146 positive regulation of fibroblast proliferation
GO:0048511 rhythmic process
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048639 positive regulation of developmental growth
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0070419 nonhomologous end joining complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1905221 positive regulation of platelet formation
GO:2000773 negative regulation of cellular senescence
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
GO:2001229 negative regulation of response to gamma radiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012582 NUC194DomainDomain
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR037706 DNA-dependent protein kinase catalytic subunit, catalytic domainDomainDomain

Diseases

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