Entity Details

Primary name CDK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP97377
EntryNameCDK2_MOUSE
FullNameCyclin-dependent kinase 2
TaxID10090
Evidenceevidence at protein level
Length346
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCdk2

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000287 magnesium ion binding
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000781 chromosome, telomeric region
GO:0000793 condensed chromosome
GO:0000805 X chromosome
GO:0000806 Y chromosome
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006813 potassium ion transport
GO:0007099 centriole replication
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010468 regulation of gene expression
GO:0015030 Cajal body
GO:0016301 kinase activity
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019904 protein domain specific binding
GO:0030332 cyclin binding
GO:0032298 positive regulation of DNA-dependent DNA replication initiation
GO:0032869 cellular response to insulin stimulus
GO:0043231 intracellular membrane-bounded organelle
GO:0044877 protein-containing complex binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0051591 response to cAMP
GO:0051602 response to electrical stimulus
GO:0060968 regulation of gene silencing
GO:0097123 cyclin A1-CDK2 complex
GO:0097124 cyclin A2-CDK2 complex
GO:0097134 cyclin E1-CDK2 complex
GO:0097135 cyclin E2-CDK2 complex
GO:0097472 cyclin-dependent protein kinase activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
CDK2_MOUSECCNA2_MOUSEBioGRID, IntAct10068472 16627785 18635963 19592082 22898779 8226784 8547220 details
CDK2_MOUSECCNE1_MOUSEBioGRID, IntAct, MINT12970760 14627988 15155733 15749021 16102793 16627785 17699765 18356301 18635963 19592082 20150892 8226784 8769642 details
CDK2_MOUSERB_HUMANBioGRID, IntAct16627785 23079656 details
CDK2_MOUSEH11_HUMANBioGRID18667424 details
CDK2_MOUSERB_MOUSEBioGRID16102793 18356301 details
CDK2_MOUSECCNA1_MOUSEBioGRID12121977 15155733 15707957 18356301 details
CDK2_MOUSEH15_HUMANBioGRID16120603 17699765 details
CDK2_MOUSECDN1B_MOUSEBioGRID11328857 16102793 22898779 8033213 8822197 details
CDK2_MOUSEBCL2_MOUSEBioGRID16102793 details
CDK2_MOUSEP53_MOUSEBioGRID16102793 details
CDK2_MOUSEH10_MOUSEBioGRID14561402 details
CDK2_MOUSEH10_HUMANBioGRID11463824 12466960 details
CDK2_MOUSETNFC_MOUSEBioGRID7604037 details
CDK2_MOUSEH11_MOUSEBioGRID12007403 14627988 15707957 15749021 17371838 8226784 8547220 details
CDK2_MOUSECEBPA_MOUSEBioGRID15107404 20516642 details
CDK2_MOUSENPM_MOUSEBioGRID16376875 details
CDK2_MOUSEH12_MOUSEBioGRID12970760 22898779 9281369 details
CDK2_MOUSEH15_MOUSEBioGRID16627785 details
CDK2_MOUSEBRCA2_MOUSEBioGRID25218637 details
CDK2_MOUSECCNC_MOUSEDIP25344755 details
CDK2_MOUSECDN1A_MOUSEBioGRID12970760 15107404 15155733 15707957 18356301 18729080 9488036 details
CDK2_MOUSEPURA_MOUSEBioGRID15707957 details
CDK2_MOUSECDC6_MOUSEBioGRID18356301 details
CDK2_MOUSESMN_MOUSEBioGRID12420317 details
CDK2_MOUSECCND2_MOUSEBioGRID9584157 details
CDK2_MOUSEPCNA_MOUSEBioGRID12970760 details
CDK2_MOUSEPA24A_MOUSEBioGRID26303530 details
CDK2_MOUSEDPPA3_MOUSEBioGRID28712289 details