Entity Details

Primary name SMAD4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP97471
EntryNameSMAD4_MOUSE
FullNameMothers against decapentaplegic homolog 4
TaxID10090
Evidenceevidence at protein level
Length551
SequenceStatuscomplete
DateCreated2001-05-04
DateModified2021-06-02

Ontological Relatives

GenesSmad4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001822 kidney development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003360 brainstem development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0007498 mesoderm development
GO:0008585 female gonad development
GO:0032525 somite rostral/caudal axis specification
GO:0042060 wound healing
GO:0042118 endothelial cell activation
GO:0042127 regulation of cell population proliferation
GO:0042733 embryonic digit morphogenesis
GO:0043199 sulfate binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0048382 mesendoderm development
GO:0048859 formation of anatomical boundary
GO:0051797 regulation of hair follicle development
GO:0060548 negative regulation of cell death
GO:0060956 endocardial cell differentiation
GO:0071333 cellular response to glucose stimulus
GO:0071559 response to transforming growth factor beta
GO:0072134 nephrogenic mesenchyme morphogenesis
GO:0072520 seminiferous tubule development
GO:0000976 transcription cis-regulatory region binding
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001666 response to hypoxia
GO:0001702 gastrulation with mouth forming second
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006879 cellular iron ion homeostasis
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0008584 male gonad development
GO:0009653 anatomical structure morphogenesis
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014033 neural crest cell differentiation
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0032909 regulation of transforming growth factor beta2 production
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048729 tissue morphogenesis
GO:0060065 uterus development
GO:0060412 ventricular septum morphogenesis
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0090575 RNA polymerase II transcription regulator complex
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001701 in utero embryonic development
GO:0003190 atrioventricular valve formation
GO:0003251 positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007492 endoderm development
GO:0009952 anterior/posterior pattern specification
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509 BMP signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031005 filamin binding
GO:0032444 activin responsive factor complex
GO:0035556 intracellular signal transduction
GO:0036302 atrioventricular canal development
GO:0042177 negative regulation of protein catabolic process
GO:0042803 protein homodimerization activity
GO:0048589 developmental growth
GO:0048663 neuron fate commitment
GO:0051098 regulation of binding
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0062009 secondary palate development
GO:0070412 R-SMAD binding
GO:0072133 metanephric mesenchyme morphogenesis
GO:1905305 negative regulation of cardiac myofibril assembly
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001541 ovarian follicle development
GO:0001649 osteoblast differentiation
GO:0003148 outflow tract septum morphogenesis
GO:0003220 left ventricular cardiac muscle tissue morphogenesis
GO:0003279 cardiac septum development
GO:0005518 collagen binding
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0007183 SMAD protein complex assembly
GO:0007369 gastrulation
GO:0007411 axon guidance
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030513 positive regulation of BMP signaling pathway
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0048733 sebaceous gland development
GO:0061040 female gonad morphogenesis
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070371 ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070411 I-SMAD binding
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:2000617 positive regulation of histone H3-K9 acetylation

Subcellular Location

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Subcellular Location
Nucleus
Cytoplasm

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
SMAD4_MOUSEPAR3_MOUSEMINT12650946 details
SMAD4_MOUSEERBIN_MOUSEMINT12650946 details
SMAD4_MOUSEDVL1_MOUSEMINT12650946 details
SMAD4_MOUSESMAD3_MOUSEBioGRID, DIP, IntAct, MINT12145309 12672795 14764653 17226765 18268325 21145499 22036565 22045334 22442258 details
SMAD4_MOUSETIAF1_HUMANUniProt21368882 details
SMAD4_MOUSEFOXP1_MOUSEBioGRID, IntAct20211142 details
SMAD4_MOUSETLX3_MOUSEBioGRID, IntAct20211142 details
SMAD4_MOUSEGATA4_MOUSEBioGRID14662776 details
SMAD4_MOUSEGATA5_MOUSEBioGRID14662776 details
SMAD4_MOUSEGATA6_MOUSEBioGRID14662776 details
SMAD4_MOUSEGA45A_MOUSEBioGRID26022109 details
SMAD4_MOUSEKGP1_MOUSEMINT19424179 details
SMAD4_MOUSESMAD2_MOUSEBioGRID, IntAct12672795 14764653 17452626 21145499 22442258 23973329 details
SMAD4_MOUSEHOP_MOUSEDIP26113728 details
SMAD4_MOUSESKI_MOUSEDIP29072299 details
SMAD4_MOUSESIN3A_MOUSEBioGRID17226765 details
SMAD4_MOUSEHDAC1_MOUSEBioGRID17226765 details
SMAD4_MOUSESNAI1_MOUSEBioGRID19597490 details
SMAD4_MOUSESMRD3_MOUSEBioGRID15525990 details
SMAD4_MOUSELEF1_MOUSEBioGRID17452626 details
SMAD4_MOUSEPEX6_MOUSEBioGRID14651998 details
SMAD4_MOUSE4ET_MOUSEBioGRID14651998 details
SMAD4_MOUSEZMYM2_MOUSEBioGRID14651998 details
SMAD4_MOUSEPBX1_MOUSEBioGRID14764653 details
SMAD4_MOUSEPKNX1_MOUSEBioGRID14764653 details
SMAD4_MOUSESMAD4_MOUSEBioGRID14764653 details
SMAD4_MOUSECO1A1_MOUSEBioGRID14559231 details
SMAD4_MOUSECO3A1_MOUSEBioGRID14559231 details
SMAD4_MOUSECO5A1_MOUSEBioGRID14559231 details
SMAD4_MOUSEPRD16_MOUSEBioGRID17467076 details
SMAD4_MOUSEFBW1A_MOUSEBioGRID26022109 details