Entity Details

Primary name PITX2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP97474
EntryNamePITX2_MOUSE
FullNamePituitary homeobox 2
TaxID10090
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPitx2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0002074 extraocular skeletal muscle development
GO:0003171 atrioventricular valve development
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003350 pulmonary myocardium development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0007520 myoblast fusion
GO:0008134 transcription factor binding
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009653 anatomical structure morphogenesis
GO:0009725 response to hormone
GO:0009887 animal organ morphogenesis
GO:0016055 Wnt signaling pathway
GO:0021763 subthalamic nucleus development
GO:0021855 hypothalamus cell migration
GO:0021983 pituitary gland development
GO:0030182 neuron differentiation
GO:0030324 lung development
GO:0030334 regulation of cell migration
GO:0031076 embryonic camera-type eye development
GO:0031490 chromatin DNA binding
GO:0033189 response to vitamin A
GO:0035116 embryonic hindlimb morphogenesis
GO:0035886 vascular associated smooth muscle cell differentiation
GO:0035993 deltoid tuberosity development
GO:0042127 regulation of cell population proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043010 camera-type eye development
GO:0043388 positive regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048536 spleen development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0051219 phosphoprotein binding
GO:0055007 cardiac muscle cell differentiation
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055015 ventricular cardiac muscle cell development
GO:0055123 digestive system development
GO:0060412 ventricular septum morphogenesis
GO:0060460 left lung morphogenesis
GO:0060577 pulmonary vein morphogenesis
GO:0060578 superior vena cava morphogenesis
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061031 endodermal digestive tract morphogenesis
GO:0061072 iris morphogenesis
GO:0061325 cell proliferation involved in outflow tract morphogenesis
GO:0070986 left/right axis specification
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000288 positive regulation of myoblast proliferation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR003654 OAR domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR016233 Homeobox protein Pitx/unc30FamilyFamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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