Entity Details

Primary name ADA1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP97718
EntryNameADA1A_MOUSE
FullNameAlpha-1A adrenergic receptor
TaxID10090
Evidenceevidence at protein level
Length466
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesAdra1a

GO terms

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GOName
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0004930 G protein-coupled receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007512 adult heart development
GO:0007568 aging
GO:0009725 response to hormone
GO:0010460 positive regulation of heart rate
GO:0010507 negative regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016020 membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031965 nuclear membrane
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035265 organ growth
GO:0042493 response to drug
GO:0043231 intracellular membrane-bounded organelle
GO:0043410 positive regulation of MAPK cascade
GO:0045760 positive regulation of action potential
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046982 protein heterodimerization activity
GO:0060073 micturition
GO:0060402 calcium ion transport into cytosol
GO:0060452 positive regulation of cardiac muscle contraction
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090037 positive regulation of protein kinase C signaling
GO:0097195 pilomotor reflex
GO:0098691 dopaminergic synapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0150099 neuron-glial cell signaling
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001004 Alpha 1A adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ADA1A_MOUSECXCR4_MOUSEIntAct27331810 details