Entity Details

Primary name BRCA2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP97929
EntryNameBRCA2_MOUSE
FullNameBreast cancer type 2 susceptibility protein homolog
TaxID10090
Evidenceevidence at protein level
Length3329
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesBrca2

GO terms

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GOName
GO:0000722 telomere maintenance via recombination
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0000800 lateral element
GO:0001556 oocyte maturation
GO:0001833 inner cell mass cell proliferation
GO:0002020 protease binding
GO:0003697 single-stranded DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007420 brain development
GO:0007569 cell aging
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008585 female gonad development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165 response to X-ray
GO:0010225 response to UV-C
GO:0010332 response to gamma radiation
GO:0010484 H3 histone acetyltransferase activity
GO:0010485 H4 histone acetyltransferase activity
GO:0030097 hemopoiesis
GO:0030141 secretory granule
GO:0030879 mammary gland development
GO:0031619 homologous chromosome orientation involved in meiotic metaphase I plate congression
GO:0032465 regulation of cytokinesis
GO:0032991 protein-containing complex
GO:0033593 BRCA2-MAGE-D1 complex
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0035264 multicellular organism growth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0043009 chordate embryonic development
GO:0043015 gamma-tubulin binding
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0048478 replication fork protection
GO:0051276 chromosome organization
GO:0051298 centrosome duplication
GO:0070200 establishment of protein localization to telomere
GO:1990426 mitotic recombination-dependent replication fork processing

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002093 BRCA2 repeatRepeatRepeat
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR015187 BRCA2, OB1DomainDomain
IPR015188 BRCA2, OB3DomainDomain
IPR015205 Tower domainDomainDomain
IPR015252 Breast cancer type 2 susceptibility protein, helical domainDomainDomain
IPR015525 Breast cancer type 2 susceptibility proteinFamilyFamily
IPR036315 BRCA2 helical domain superfamilyFamilyHomologous superfamily

Diseases

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