Entity Details

Primary name DAB2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP98078
EntryNameDAB2_MOUSE
FullNameDisabled homolog 2
TaxID10090
Evidenceevidence at protein level
Length766
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesDab2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000904 cell morphogenesis involved in differentiation
GO:0001650 fibrillar center
GO:0001701 in utero embryonic development
GO:0001921 positive regulation of receptor recycling
GO:0001934 positive regulation of protein phosphorylation
GO:0002092 positive regulation of receptor internalization
GO:0005178 integrin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006898 receptor-mediated endocytosis
GO:0006907 pinocytosis
GO:0006915 apoptotic process
GO:0007257 obsolete activation of JUN kinase activity
GO:0007492 endoderm development
GO:0007588 excretion
GO:0008022 protein C-terminus binding
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010977 negative regulation of neuron projection development
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0030099 myeloid cell differentiation
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030276 clathrin binding
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030665 clathrin-coated vesicle membrane
GO:0032091 negative regulation of protein binding
GO:0032349 positive regulation of aldosterone biosynthetic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0035026 leading edge cell differentiation
GO:0035091 phosphatidylinositol binding
GO:0035612 AP-2 adaptor complex binding
GO:0035615 clathrin adaptor activity
GO:0038024 cargo receptor activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048268 clathrin coat assembly
GO:0048471 perinuclear region of cytoplasm
GO:0048545 response to steroid hormone
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071425 hematopoietic stem cell proliferation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1903077 negative regulation of protein localization to plasma membrane
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity
GO:2000370 positive regulation of clathrin-dependent endocytosis
GO:2000643 positive regulation of early endosome to late endosome transport
GO:2000860 positive regulation of aldosterone secretion
GO:2001046 positive regulation of integrin-mediated signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR006020 PTB/PI domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
DAB2_MOUSEITB5_HUMANMINT12606711 details
DAB2_MOUSEITB3_HUMANMINT12606711 details
DAB2_MOUSEITB7_HUMANMINT12606711 details
DAB2_MOUSENOSTN_MOUSEBioGRID, UniProt15596140 32325033 details
DAB2_MOUSENECP1_MOUSEMINT17762867 details
DAB2_MOUSEMYO6_HUMANUniProt11967127 22323290 details
DAB2_MOUSEFCHO2_HUMANUniProt22323290 details
DAB2_MOUSEEPS15_HUMANBioGRID, UniProt22323290 22648170 details
DAB2_MOUSEPIAS2_MOUSEUniProt11104669 details
DAB2_MOUSEA4_MOUSEUniProt12826668 details
DAB2_MOUSEEP15R_MOUSEUniProt22648170 details
DAB2_MOUSEEPS15_MOUSEUniProt22648170 details
DAB2_MOUSEAXIN1_MOUSEMINT, UniProt12805222 19581931 details
DAB2_MOUSEPP1A_MOUSEMINT19581931 details
DAB2_MOUSEAP2A2_HUMANUniProt22323290 details
DAB2_MOUSEGRB2_HUMANUniProt22323290 9569023 details
DAB2_MOUSEGRB2_MOUSEUniProt9569023 details
DAB2_MOUSECSF1R_MOUSEUniProt9569023 details
DAB2_MOUSEDVL2_HUMANUniProt12805222 details
DAB2_MOUSEDVL1_HUMANUniProt12805222 details
DAB2_MOUSEDVL3_HUMANUniProt12805222 details
DAB2_MOUSEDVL2_MOUSEUniProt12805222 details
DAB2_MOUSEDVL3_MOUSEUniProt12805222 details
DAB2_MOUSEITB1_MOUSEUniProt15734730 details
DAB2_MOUSEM3K7_MOUSEUniProt15894542 details
DAB2_MOUSEITSN1_MOUSEUniProt22648170 details
DAB2_MOUSESH3K1_HUMANUniProt14596919 details
DAB2_MOUSESH3K1_MOUSEUniProt14596919 details
DAB2_MOUSEVGFR3_MOUSEDIP23354168 details
DAB2_MOUSEPARD3_MOUSEDIP23354168 details
DAB2_MOUSET22D3_MOUSEBioGRID11104669 details
DAB2_MOUSEITSN1_HUMANBioGRID22648170 details
DAB2_MOUSELRP2_MOUSEBioGRID12413896 details
DAB2_MOUSETSC1_MOUSEBioGRID32133736 details