Entity Details

Primary name SHC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP98083
EntryNameSHC1_MOUSE
FullNameSHC-transforming protein 1
TaxID10090
Evidenceevidence at protein level
Length579
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesShc1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001525 angiogenesis
GO:0001784 phosphotyrosine residue binding
GO:0005154 epidermal growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006940 regulation of smooth muscle contraction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007507 heart development
GO:0007568 aging
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010008 endosome membrane
GO:0016525 negative regulation of angiogenesis
GO:0019901 protein kinase binding
GO:0030036 actin cytoskeleton organization
GO:0030182 neuron differentiation
GO:0030971 receptor tyrosine kinase binding
GO:0031175 neuron projection development
GO:0031532 actin cytoskeleton reorganization
GO:0040008 regulation of growth
GO:0042127 regulation of cell population proliferation
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0044877 protein-containing complex binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0046875 ephrin receptor binding
GO:0048408 epidermal growth factor binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051219 phosphoprotein binding
GO:0051721 protein phosphatase 2A binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070435 Shc-EGFR complex
GO:0071363 cellular response to growth factor stimulus
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0090322 regulation of superoxide metabolic process
GO:0098609 cell-cell adhesion
GO:1990839 response to endothelin

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR006019 Phosphotyrosine interaction domain, Shc-likeDomainDomain
IPR006020 PTB/PI domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR029586 SHC-transforming protein 1FamilyFamily
IPR035676 SH2 adaptor protein C, SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
SHC1_MOUSESHIP1_MOUSEBioGRID, IntAct10068665 10748054 20697350 8723348 9393882 details
SHC1_MOUSEGRB2_MOUSEBioGRID, IntAct, MINT10362356 10748054 10995764 11259577 17673906 18273058 20697350 23452850 7529871 7535773 7538132 7689150 8479540 9013573 details
SHC1_MOUSEITB7_HUMANMINT12606711 details
SHC1_MOUSEGAB1_MOUSEBioGRID, MINT10871282 12808090 details
SHC1_MOUSEDCAM1_MOUSEIntAct15102471 details
SHC1_MOUSESHCBP_MOUSEIntAct15102471 details
SHC1_MOUSEBMAL1_MOUSEIntAct15102471 details
SHC1_MOUSETAXB1_MOUSEIntAct15102471 details
SHC1_MOUSEBRSK1_MOUSEIntAct15102471 details
SHC1_MOUSEIQGA1_MOUSEMINT20075861 details
SHC1_MOUSEPTN12_MOUSEBioGRID, IntAct, MINT12052829 20075861 20697350 details
SHC1_MOUSESHC1_MOUSEDIP18413607 details
SHC1_MOUSEMK14_MOUSEBioGRID16251354 details
SHC1_MOUSEGRB2_HUMANBioGRID10202139 10995764 details
SHC1_MOUSEGRAP2_MOUSEBioGRID9872323 details
SHC1_MOUSEP85A_MOUSEBioGRID10995764 details
SHC1_MOUSENTRK1_MOUSEBioGRID8610109 details
SHC1_MOUSEEGFR_HUMANIntAct8887653 details
SHC1_MOUSETGFR2_MOUSEMINT17673906 details
SHC1_MOUSETGFR1_MOUSEDIP, MINT17673906 26680585 details
SHC1_MOUSESOS1_MOUSEBioGRID, MINT17673906 8479540 9013573 details
SHC1_MOUSEIQGA1_HUMANMINT20075861 details
SHC1_MOUSESHIP2_MOUSEBioGRID, IntAct14502564 20697350 details
SHC1_MOUSEIRS1_MOUSEIntAct11259577 details
SHC1_MOUSEERBB3_HUMANBioGRID9694850 details
SHC1_MOUSESOCS1_MOUSEBioGRID20622265 details
SHC1_MOUSEA4_HUMANBioGRID17384289 details
SHC1_MOUSECSF1R_MOUSEBioGRID10330148 details
SHC1_MOUSEPTN11_MOUSEBioGRID9393882 details
SHC1_MOUSEERBB2_MOUSEBioGRID10940298 details
SHC1_MOUSEALK_MOUSEBioGRID15226403 details
SHC1_MOUSEEGFR_MOUSEBioGRID20676128 7538132 7689150 details
SHC1_MOUSESRC_MOUSEBioGRID15716419 details
SHC1_MOUSESOCS4_HUMANBioGRID23990909 details
SHC1_MOUSERET_HUMANBioGRID10995764 details
SHC1_MOUSEUFO_MOUSEBioGRID8610109 details