Entity Details

Primary name PAX8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ00288
EntryNamePAX8_MOUSE
FullNamePaired box protein Pax-8
TaxID10090
Evidenceevidence at protein level
Length457
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesPax8

GO terms

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GOName
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001823 mesonephros development
GO:0003281 ventricular septum development
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006790 sulfur compound metabolic process
GO:0007417 central nervous system development
GO:0009887 animal organ morphogenesis
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0030154 cell differentiation
GO:0030878 thyroid gland development
GO:0039003 pronephric field specification
GO:0042472 inner ear morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048793 pronephros development
GO:0048856 anatomical structure development
GO:0071371 cellular response to gonadotropin stimulus
GO:0072050 S-shaped body morphogenesis
GO:0072073 kidney epithelium development
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072164 mesonephric tubule development
GO:0072221 metanephric distal convoluted tubule development
GO:0072289 metanephric nephron tubule formation
GO:0072305 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215 negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218 negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000594 positive regulation of metanephric DCT cell differentiation
GO:2000611 positive regulation of thyroid hormone generation
GO:2000612 regulation of thyroid-stimulating hormone secretion

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001523 Paired domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR022130 Paired-box protein 2 C-terminalDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR043182 Paired DNA-binding domainDomainDomain
IPR043565 PAX familyFamilyFamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
PAX8_MOUSEPAXI1_MOUSEUniProt10908331 details
PAX8_MOUSENKX21_MOUSEBioGRID, IntAct20211142 details
PAX8_MOUSEJADE1_MOUSEBioGRID, IntAct20211142 details