Entity Details

Primary name FLT3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ00342
EntryNameFLT3_MOUSE
FullNameReceptor-type tyrosine-protein kinase FLT3
TaxID10090
Evidenceevidence at protein level
Length1000
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesFlt3

GO terms

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GOName
GO:0001776 leukocyte homeostasis
GO:0001934 positive regulation of protein phosphorylation
GO:0002318 myeloid progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002328 pro-B cell differentiation
GO:0002572 pro-T cell differentiation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004896 cytokine receptor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008285 negative regulation of cell population proliferation
GO:0009791 post-embryonic development
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0019221 cytokine-mediated signaling pathway
GO:0019838 growth factor binding
GO:0019882 antigen processing and presentation
GO:0030097 hemopoiesis
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0031625 ubiquitin protein ligase binding
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032727 positive regulation of interferon-alpha production
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0035259 glucocorticoid receptor binding
GO:0035726 common myeloid progenitor cell proliferation
GO:0036145 dendritic cell homeostasis
GO:0040018 positive regulation of multicellular organism growth
GO:0043235 receptor complex
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043621 protein self-association
GO:0044877 protein-containing complex binding
GO:0045578 negative regulation of B cell differentiation
GO:0046651 lymphocyte proliferation
GO:0046777 protein autophosphorylation
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048873 homeostasis of number of cells within a tissue
GO:0071345 cellular response to cytokine stimulus
GO:0097028 dendritic cell differentiation
GO:0098586 cellular response to virus

Subcellular Location

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Subcellular Location
Endoplasmic reticulum lumen
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR030118 Receptor-type tyrosine-protein kinase FLT3FamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions