Entity Details

Primary name XDH_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ00519
EntryNameXDH_MOUSE
FullNameXanthine dehydrogenase/oxidase
TaxID10090
Evidenceevidence at protein level
Length1335
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesXdh

GO terms

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GOName
GO:0001933 negative regulation of protein phosphorylation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0004854 xanthine dehydrogenase activity
GO:0004855 xanthine oxidase activity
GO:0005506 iron ion binding
GO:0005615 extracellular space
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0006148 inosine catabolic process
GO:0006154 adenosine catabolic process
GO:0006196 AMP catabolic process
GO:0006204 IMP catabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007595 lactation
GO:0009055 electron transfer activity
GO:0009114 hypoxanthine catabolic process
GO:0009115 xanthine catabolic process
GO:0010044 response to aluminum ion
GO:0010629 negative regulation of gene expression
GO:0016226 iron-sulfur cluster assembly
GO:0016491 oxidoreductase activity
GO:0016529 sarcoplasmic reticulum
GO:0030151 molybdenum ion binding
GO:0030856 regulation of epithelial cell differentiation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043546 molybdopterin cofactor binding
GO:0045602 negative regulation of endothelial cell differentiation
GO:0046038 GMP catabolic process
GO:0046055 dGMP catabolic process
GO:0050421 nitrite reductase (NO-forming) activity
GO:0050660 flavin adenine dinucleotide binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0070674 hypoxanthine dehydrogenase activity
GO:0070675 hypoxanthine oxidase activity
GO:0071949 FAD binding
GO:1900745 positive regulation of p38MAPK cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001213 negative regulation of vasculogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Peroxisome
Secreted

Domains

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DomainNameCategoryType
IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerheadDomainDomain
IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domainDomainDomain
IPR002346 Molybdopterin dehydrogenase, FAD-bindingDomainDomain
IPR002888 [2Fe-2S]-bindingDomainDomain
IPR005107 CO dehydrogenase flavoprotein, C-terminalDomainDomain
IPR006058 2Fe-2S ferredoxin, iron-sulphur binding siteSiteBinding site
IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin bindingDomainDomain
IPR014307 Xanthine dehydrogenase, small subunitDomainDomain
IPR014309 Xanthine dehydrogenase, molybdopterin binding subunitDomainDomain
IPR016166 FAD-binding domain, PCMH-typeDomainDomain
IPR016208 Aldehyde oxidase/xanthine dehydrogenaseFamilyFamily
IPR022407 Oxidoreductase, molybdopterin binding siteSiteBinding site
IPR036010 2Fe-2S ferredoxin-like superfamilyFamilyHomologous superfamily
IPR036318 FAD-binding, type PCMH-like superfamilyFamilyHomologous superfamily
IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamilyFamilyHomologous superfamily
IPR036884 [2Fe-2S]-binding domain superfamilyFamilyHomologous superfamily
IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
XDH_MOUSEITB1_MOUSEBioGRID30333137 details