Entity Details

Primary name ITA4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ00651
EntryNameITA4_MOUSE
FullNameIntegrin alpha-4
TaxID10090
Evidenceevidence at protein level
Length1039
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesItga4

GO terms

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GOName
GO:0001968 fibronectin binding
GO:0001974 blood vessel remodeling
GO:0002687 positive regulation of leukocyte migration
GO:0003366 cell-matrix adhesion involved in ameboidal cell migration
GO:0003823 antigen binding
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016477 cell migration
GO:0030426 growth cone
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034669 integrin alpha4-beta7 complex
GO:0043025 neuronal cell body
GO:0043113 receptor clustering
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
GO:0050901 leukocyte tethering or rolling
GO:0050904 diapedesis
GO:0060324 face development
GO:0060385 axonogenesis involved in innervation
GO:0060485 mesenchyme development
GO:0060710 chorio-allantoic fusion
GO:0061032 visceral serous pericardium development
GO:0070062 extracellular exosome
GO:0072678 T cell migration
GO:0090074 negative regulation of protein homodimerization activity
GO:0098609 cell-cell adhesion
GO:0098657 import into cell
GO:0140039 cell-cell adhesion in response to extracellular stimulus
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903238 positive regulation of leukocyte tethering or rolling
GO:1904646 cellular response to amyloid-beta
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1990138 neuron projection extension
GO:1990405 protein antigen binding
GO:1990771 clathrin-dependent extracellular exosome endocytosis
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000406 positive regulation of T cell migration

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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