Entity Details

Primary name PDE4D_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ01063
EntryNamePDE4D_MOUSE
FullNamecAMP-specific 3',5'-cyclic phosphodiesterase 4D
TaxID10090
Evidenceevidence at protein level
Length747
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPde4d

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005891 voltage-gated calcium channel complex
GO:0006198 cAMP catabolic process
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007568 aging
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016324 apical plasma membrane
GO:0030593 neutrophil chemotaxis
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034704 calcium channel complex
GO:0035264 multicellular organism growth
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0044325 transmembrane transporter binding
GO:0045822 negative regulation of heart contraction
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050900 leukocyte migration
GO:0051117 ATPase binding
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 establishment of endothelial barrier
GO:0071222 cellular response to lipopolysaccharide
GO:0071872 cellular response to epinephrine stimulus
GO:0086004 regulation of cardiac muscle cell contraction
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 negative regulation of relaxation of cardiac muscle

Subcellular Location

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Subcellular Location
Apical cell membrane
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily
IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)DomainDomain

Diseases

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Interactions

3 interactions