Entity Details

Primary name NMDE2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ01097
EntryNameNMDE2_MOUSE
FullNameGlutamate receptor ionotropic, NMDA 2B
TaxID10090
Evidenceevidence at protein level
Length1482
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesGrin2b

GO terms

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GOName
GO:0001508 action potential
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 NMDA glutamate receptor activity
GO:0005102 signaling receptor binding
GO:0005149 interleukin-1 receptor binding
GO:0005234 extracellularly glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007268 chemical synaptic transmission
GO:0007423 sensory organ development
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0008013 beta-catenin binding
GO:0008021 synaptic vesicle
GO:0008270 zinc ion binding
GO:0008306 associative learning
GO:0009986 cell surface
GO:0010243 response to organonitrogen compound
GO:0010738 regulation of protein kinase A signaling
GO:0010942 positive regulation of cell death
GO:0014049 positive regulation of glutamate secretion
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0016020 membrane
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0017146 NMDA selective glutamate receptor complex
GO:0022849 glutamate-gated calcium ion channel activity
GO:0030018 Z disc
GO:0030658 transport vesicle membrane
GO:0031749 D2 dopamine receptor binding
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035255 ionotropic glutamate receptor binding
GO:0036094 small molecule binding
GO:0038023 signaling receptor activity
GO:0042165 neurotransmitter binding
GO:0042596 fear response
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043083 synaptic cleft
GO:0043113 receptor clustering
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043408 regulation of MAPK cascade
GO:0044307 dendritic branch
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045471 response to ethanol
GO:0046960 sensitization
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048266 behavioral response to pain
GO:0048511 rhythmic process
GO:0050806 positive regulation of synaptic transmission
GO:0050839 cell adhesion molecule binding
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051290 protein heterotetramerization
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0060291 long-term synaptic potentiation
GO:0097060 synaptic membrane
GO:0097110 scaffold protein binding
GO:0097440 apical dendrite
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098688 parallel fiber to Purkinje cell synapse
GO:0098794 postsynapse
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse
GO:0098989 NMDA selective glutamate receptor signaling pathway
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration
GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1901216 positive regulation of neuron death
GO:1902951 negative regulation of dendritic spine maintenance
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:2001056 positive regulation of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
NMDE2_MOUSEDLG4_MOUSEBioGRID, DIP, IntAct, MINT10862698 15663482 16332682 16554481 16635246 16710293 17950729 19240213 19243221 19455133 20141836 20467438 22234183 23760271 27507650 28671696 9647694 details
NMDE2_MOUSEDAPK1_MOUSEIntAct20141836 details
NMDE2_MOUSEINADL_MOUSEBioGRID9647694 details
NMDE2_MOUSENMDZ1_MOUSEBioGRID, DIP, IntAct, MINT10862698 14645471 15663482 16554481 16635246 19243221 20141836 32033586 9003035 details
NMDE2_MOUSEACTN2_MOUSEBioGRID, IntAct, MINT10862698 16635246 16710293 details
NMDE2_MOUSEKCC2A_MOUSEBioGRID, IntAct, MINT10862698 16635246 16710293 20141836 22234183 24725413 24734203 details
NMDE2_MOUSENMDE1_MOUSEBioGRID, IntAct, MINT10862698 14645471 16554481 16635246 details
NMDE2_MOUSECLH1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEMTAP2_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSECADH2_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEDSG1A_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSESHAN2_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSESRC8_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSECTNB1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEPLCG1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSENOS1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEPA24A_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSECALM1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSECALM2_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSECALM3_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEARC_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSENF1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSECTRO_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSERALA_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSERAC1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSERASH_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEPTN5_MOUSEBioGRID, IntAct16635246 27457929 details
NMDE2_MOUSEPPP5_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSESRC_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEFAK2_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEKS6A3_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSERAF1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEKPCG_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEKPCE_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEKPCB_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEKAP3_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEDUS4_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEMP2K2_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEMP2K1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEMK01_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEMK03_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEHOME1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEPP2AA_MOUSEBioGRID, IntAct10862698 16635246 details
NMDE2_MOUSEAP2A1_MOUSEMINT16710293 details
NMDE2_MOUSESYGP1_MOUSEBioGRID, IntAct10862698 27507650 28671696 28706196 details
NMDE2_MOUSERHG32_MOUSEBioGRID12531901 details
NMDE2_MOUSEAKAP9_MOUSEBioGRID10862698 details
NMDE2_MOUSEAKAP5_MOUSEBioGRID10862698 details
NMDE2_MOUSEKAPCA_MOUSEBioGRID10862698 details
NMDE2_MOUSEPP1G_MOUSEBioGRID10862698 details
NMDE2_MOUSEKS6A1_MOUSEBioGRID10862698 details
NMDE2_MOUSERAP1A_MOUSEBioGRID10862698 details
NMDE2_MOUSEP85A_MOUSEBioGRID10862698 details
NMDE2_MOUSECTND1_MOUSEBioGRID10862698 details
NMDE2_MOUSEACTC_MOUSEBioGRID10862698 details
NMDE2_MOUSESPTA1_MOUSEBioGRID10862698 details
NMDE2_MOUSELIN7C_MOUSEBioGRID16186258 details
NMDE2_MOUSESHC2_MOUSEBioGRID15716419 details
NMDE2_MOUSESHC3_MOUSEBioGRID15716419 details
NMDE2_MOUSELRP1_MOUSEBioGRID23760271 details
NMDE2_MOUSENEB2_MOUSEBioGRID30562941 details
NMDE2_MOUSEPDE10_MOUSEBioGRID25762721 details