Entity Details

Primary name HMDH_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ01237
EntryNameHMDH_MOUSE
FullName3-hydroxy-3-methylglutaryl-coenzyme A reductase
TaxID10090
Evidenceevidence at protein level
Length887
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesHmgcr

GO terms

Show/Hide Table
GOName
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006695 cholesterol biosynthetic process
GO:0006743 ubiquinone metabolic process
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell population proliferation
GO:0008299 isoprenoid biosynthetic process
GO:0008542 visual learning
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0015936 coenzyme A metabolic process
GO:0016021 integral component of membrane
GO:0016126 sterol biosynthetic process
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0038183 bile acid signaling pathway
GO:0042177 negative regulation of protein catabolic process
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043407 negative regulation of MAP kinase activity
GO:0045445 myoblast differentiation
GO:0045471 response to ethanol
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050709 negative regulation of protein secretion
GO:0051721 protein phosphatase 2A binding
GO:0061045 negative regulation of wound healing
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070328 triglyceride homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070402 NADPH binding
GO:0070723 response to cholesterol
GO:0120225 coenzyme A binding
GO:1900222 negative regulation of amyloid-beta clearance

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane
Peroxisome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000731 Sterol-sensing domainDomainDomain
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/IIFamilyFamily
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal typeFamilyFamily
IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoanFamilyFamily
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamilyFamilyHomologous superfamily
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamilyFamilyHomologous superfamily
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamilyFamilyHomologous superfamily
IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved siteSiteConserved site
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminalFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink