Entity Details

Primary name EGFR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ01279
EntryNameEGFR_MOUSE
FullNameEpidermal growth factor receptor
TaxID10090
Evidenceevidence at protein level
Length1210
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesEgfr

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000186 obsolete activation of MAPKK activity
GO:0000902 cell morphogenesis
GO:0001892 embryonic placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0003682 chromatin binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006412 translation
GO:0006970 response to osmotic stress
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007435 salivary gland morphogenesis
GO:0007494 midgut development
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008544 epidermis development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0010960 magnesium ion homeostasis
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016101 diterpenoid metabolic process
GO:0016301 kinase activity
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0021795 cerebral cortex cell migration
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0031625 ubiquitin protein ligase binding
GO:0031901 early endosome membrane
GO:0031965 nuclear membrane
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033590 response to cobalamin
GO:0033594 response to hydroxyisoflavone
GO:0033674 positive regulation of kinase activity
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042327 positive regulation of phosphorylation
GO:0042698 ovulation cycle
GO:0042743 hydrogen peroxide metabolic process
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043586 tongue development
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045780 positive regulation of bone resorption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048143 astrocyte activation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048408 epidermal growth factor binding
GO:0048471 perinuclear region of cytoplasm
GO:0048546 digestive tract morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048812 neuron projection morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051015 actin filament binding
GO:0051592 response to calcium ion
GO:0051897 positive regulation of protein kinase B signaling
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060252 positive regulation of glial cell proliferation
GO:0060571 morphogenesis of an epithelial fold
GO:0061029 eyelid development in camera-type eye
GO:0070141 response to UV-A
GO:0070257 positive regulation of mucus secretion
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097421 liver regeneration
GO:0097489 multivesicular body, internal vesicle lumen
GO:0098609 cell-cell adhesion
GO:1900020 positive regulation of protein kinase C activity
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902722 positive regulation of prolactin secretion
GO:1902966 positive regulation of protein localization to early endosome
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905208 negative regulation of cardiocyte differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Endosome
Endosome membrane
Golgi apparatus membrane
Nucleus
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
EGFR_MOUSEEPS15_MOUSEBioGRID, MINT10953014 16862145 details
EGFR_MOUSEEGF_HUMANMINT21439278 details
EGFR_MOUSECBL_MOUSEBioGRID, MINT14691459 17139251 17372273 20298671 23027125 23457600 23799367 32325033 7657591 details
EGFR_MOUSEGRB2_MOUSEBioGRID, MINT11896055 17372273 20676128 23027125 23799367 7689150 8264620 9363897 details
EGFR_MOUSEJAK2_MOUSEBioGRID9038232 9363897 details
EGFR_MOUSESTAT1_HUMANBioGRID7657660 details
EGFR_MOUSEEGFR_MOUSEBioGRID20676128 details
EGFR_MOUSEVAV_MOUSEBioGRID7689150 details
EGFR_MOUSEOTUD4_HUMANBioGRID31138677 details
EGFR_MOUSEDOK2_MOUSEMINT15831486 details
EGFR_MOUSESOCS5_MOUSEBioGRID, MINT15695332 details
EGFR_MOUSEEGF_MOUSEMINT2022652 details
EGFR_MOUSEPTN1_HUMANMINT18515860 details
EGFR_MOUSEPTN12_MOUSEMINT12614164 details
EGFR_MOUSERASK_MOUSEIntAct22975374 details
EGFR_MOUSERAGE_HUMANDIP16954185 details
EGFR_MOUSEITB3_MOUSEDIP17606926 details
EGFR_MOUSELIGO1_MOUSEDIP17726113 details
EGFR_MOUSEUBB_MOUSEDIP20308550 details
EGFR_MOUSEUBC_MOUSEDIP20308550 details
EGFR_MOUSERS27A_MOUSEDIP20308550 details
EGFR_MOUSERL40_MOUSEDIP20308550 details
EGFR_MOUSECHIA_MOUSEIntAct18824549 details
EGFR_MOUSELRIG1_MOUSEIntAct15345710 details
EGFR_MOUSEPRKN_HUMANBioGRID16862145 details
EGFR_MOUSEMK14_MOUSEBioGRID17139251 details
EGFR_MOUSEARHG7_MOUSEBioGRID16892055 details
EGFR_MOUSEERBB2_MOUSEBioGRID21044682 23027125 details
EGFR_MOUSETYK2_MOUSEBioGRID9038232 details
EGFR_MOUSESRC_MOUSEBioGRID11274221 details
EGFR_MOUSESHC1_MOUSEBioGRID20676128 7538132 7689150 details
EGFR_MOUSEASPP1_MOUSEBioGRID23027125 details
EGFR_MOUSEPTN11_MOUSEBioGRID23027125 details
EGFR_MOUSESOS1_MOUSEBioGRID23027125 8479540 details
EGFR_MOUSEOSMR_MOUSEBioGRID27110918 details
EGFR_MOUSEEGFR_HUMANBioGRID2915986 details
EGFR_MOUSEITB4_MOUSEBioGRID25202019 details
EGFR_MOUSEAP2A1_MOUSEBioGRID7534311 details
EGFR_MOUSEAP1B1_MOUSEBioGRID7534311 details