Entity Details

Primary name TOP2A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ01320
EntryNameTOP2A_MOUSE
FullNameDNA topoisomerase 2-alpha
TaxID10090
Evidenceevidence at protein level
Length1528
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesTop2a

GO terms

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GOName
GO:0000228 nuclear chromosome
GO:0000287 magnesium ion binding
GO:0000712 resolution of meiotic recombination intermediates
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0007143 female meiotic nuclear division
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008301 DNA binding, bending
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0019899 enzyme binding
GO:0030261 chromosome condensation
GO:0030263 apoptotic chromosome condensation
GO:0032991 protein-containing complex
GO:0040016 embryonic cleavage
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0043565 sequence-specific DNA binding
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048511 rhythmic process
GO:0051309 female meiosis chromosome separation
GO:1905463 negative regulation of DNA duplex unwinding
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001241 DNA topoisomerase, type IIAFamilyFamily
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminalDomainDomain
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR006171 TOPRIM domainDomainDomain
IPR012542 DTHCTDomainDomain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2DomainDomain
IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-betaFamilyHomologous superfamily
IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminalFamilyHomologous superfamily
IPR013760 DNA topoisomerase, type IIA-like domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR018522 DNA topoisomerase, type IIA, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR031660 C-terminal associated domain of TOPRIMDomainDomain
IPR034157 DNA topoisomerase 2, TOPRIM domainDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily

Diseases

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