Entity Details

Primary name ADA2A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ01338
EntryNameADA2A_MOUSE
FullNameAlpha-2A adrenergic receptor
TaxID10090
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesAdra2a

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0002526 acute inflammatory response
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004938 alpha2-adrenergic receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006260 DNA replication
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007565 female pregnancy
GO:0019229 regulation of vasoconstriction
GO:0019901 protein kinase binding
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0031696 alpha-2C adrenergic receptor binding
GO:0031996 thioesterase binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032795 heterotrimeric G-protein binding
GO:0032870 cellular response to hormone stimulus
GO:0035624 receptor transactivation
GO:0042593 glucose homeostasis
GO:0042596 fear response
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043679 axon terminus
GO:0045202 synapse
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0046982 protein heterodimerization activity
GO:0050955 thermoception
GO:0050995 negative regulation of lipid catabolic process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051379 epinephrine binding
GO:0051380 norepinephrine binding
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070473 negative regulation of uterine smooth muscle contraction
GO:0071875 adrenergic receptor signaling pathway
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO:0071882 phospholipase C-activating adrenergic receptor signaling pathway
GO:0090303 positive regulation of wound healing
GO:0098691 dopaminergic synapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099059 integral component of presynaptic active zone membrane
GO:0099061 integral component of postsynaptic density membrane
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001946 Alpha 2A adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ADA2A_MOUSEEI2BA_HUMANIntAct9235896 details
ADA2A_MOUSEARBK1_MOUSEBioGRID15218143 details