Entity Details

Primary name NOTC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ01705
EntryNameNOTC1_MOUSE
FullNameNeurogenic locus notch homolog protein 1
TaxID10090
Evidenceevidence at protein level
Length2531
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNotch1

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0002040 sprouting angiogenesis
GO:0003151 outflow tract morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003264 regulation of cardioblast proliferation
GO:0003273 cell migration involved in endocardial cushion formation
GO:0003332 negative regulation of extracellular matrix constituent secretion
GO:0003344 pericardium morphogenesis
GO:0004888 transmembrane signaling receptor activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0007492 endoderm development
GO:0007507 heart development
GO:0009912 auditory receptor cell fate commitment
GO:0010001 glial cell differentiation
GO:0010629 negative regulation of gene expression
GO:0014807 regulation of somitogenesis
GO:0030182 neuron differentiation
GO:0030324 lung development
GO:0030334 regulation of cell migration
GO:0030900 forebrain development
GO:0031490 chromatin DNA binding
GO:0043086 negative regulation of catalytic activity
GO:0043235 receptor complex
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045967 negative regulation of growth rate
GO:0048663 neuron fate commitment
GO:0048711 positive regulation of astrocyte differentiation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048873 homeostasis of number of cells within a tissue
GO:0050679 positive regulation of epithelial cell proliferation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0060411 cardiac septum morphogenesis
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060842 arterial endothelial cell differentiation
GO:0061384 heart trabecula morphogenesis
GO:0062043 positive regulation of cardiac epithelial to mesenchymal transition
GO:0070986 left/right axis specification
GO:0071944 cell periphery
GO:1902339 positive regulation of apoptotic process involved in morphogenesis
GO:2000737 negative regulation of stem cell differentiation
GO:2001027 negative regulation of endothelial cell chemotaxis
GO:0001708 cell fate specification
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0003157 endocardium development
GO:0003160 endocardium morphogenesis
GO:0003182 coronary sinus valve morphogenesis
GO:0003192 mitral valve formation
GO:0003209 cardiac atrium morphogenesis
GO:0005509 calcium ion binding
GO:0005829 cytosol
GO:0007411 axon guidance
GO:0008285 negative regulation of cell population proliferation
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010832 negative regulation of myotube differentiation
GO:0016324 apical plasma membrane
GO:0021515 cell differentiation in spinal cord
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0032495 response to muramyl dipeptide
GO:0035148 tube formation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0042246 tissue regeneration
GO:0042802 identical protein binding
GO:0045070 positive regulation of viral genome replication
GO:0045165 cell fate commitment
GO:0045608 negative regulation of inner ear auditory receptor cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048709 oligodendrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050768 negative regulation of neurogenesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0061344 regulation of cell adhesion involved in heart morphogenesis
GO:0070168 negative regulation of biomineral tissue development
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1903849 positive regulation of aorta morphogenesis
GO:0001669 acrosomal vesicle
GO:0001726 ruffle
GO:0001889 liver development
GO:0001947 heart looping
GO:0002051 osteoblast fate commitment
GO:0002052 positive regulation of neuroblast proliferation
GO:0002437 inflammatory response to antigenic stimulus
GO:0003169 coronary vein morphogenesis
GO:0003207 cardiac chamber formation
GO:0003213 cardiac right atrium morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003219 cardiac right ventricle formation
GO:0003241 growth involved in heart morphogenesis
GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003713 transcription coactivator activity
GO:0004857 enzyme inhibitor activity
GO:0005112 Notch binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006959 humoral immune response
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007409 axonogenesis
GO:0007440 foregut morphogenesis
GO:0008284 positive regulation of cell population proliferation
GO:0008544 epidermis development
GO:0008593 regulation of Notch signaling pathway
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014031 mesenchymal cell development
GO:0021915 neural tube development
GO:0031069 hair follicle morphogenesis
GO:0031100 animal organ regeneration
GO:0032496 response to lipopolysaccharide
GO:0035914 skeletal muscle cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048103 somatic stem cell division
GO:0048708 astrocyte differentiation
GO:0048845 venous blood vessel morphogenesis
GO:0050434 positive regulation of viral transcription
GO:0060253 negative regulation of glial cell proliferation
GO:0060271 cilium assembly
GO:0060412 ventricular septum morphogenesis
GO:0060740 prostate gland epithelium morphogenesis
GO:0060843 venous endothelial cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060982 coronary artery morphogenesis
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0072044 collecting duct development
GO:0072144 glomerular mesangial cell development
GO:0097150 neuronal stem cell population maintenance
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1901189 positive regulation of ephrin receptor signaling pathway
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000811 negative regulation of anoikis
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0001837 epithelial to mesenchymal transition
GO:0003162 atrioventricular node development
GO:0003184 pulmonary valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003682 chromatin binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005887 integral component of plasma membrane
GO:0007219 Notch signaling pathway
GO:0007386 compartment pattern specification
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0019899 enzyme binding
GO:0030216 keratinocyte differentiation
GO:0030279 negative regulation of ossification
GO:0030326 embryonic limb morphogenesis
GO:0030514 negative regulation of BMP signaling pathway
GO:0031410 cytoplasmic vesicle
GO:0031960 response to corticosteroid
GO:0035116 embryonic hindlimb morphogenesis
GO:0042127 regulation of cell population proliferation
GO:0045596 negative regulation of cell differentiation
GO:0045607 regulation of inner ear auditory receptor cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050678 regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060354 negative regulation of cell adhesion molecule production
GO:0060548 negative regulation of cell death
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0060956 endocardial cell differentiation
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072017 distal tubule development
GO:1901201 regulation of extracellular matrix assembly
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:2000974 negative regulation of pro-B cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022362 Neurogenic locus Notch 1FamilyFamily
IPR024600 Domain of unknown function DUF3454, notchDomainDomain
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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