Entity Details

Primary name CTNB1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ02248
EntryNameCTNB1_MOUSE
FullNameCatenin beta-1
TaxID10090
Evidenceevidence at protein level
Length781
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesCtnnb1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0000578 embryonic axis specification
GO:0000791 euchromatin
GO:0000904 cell morphogenesis involved in differentiation
GO:0000922 spindle pole
GO:0001221 transcription coregulator binding
GO:0001501 skeletal system development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001711 endodermal cell fate commitment
GO:0001764 neuron migration
GO:0001822 kidney development
GO:0001840 neural plate development
GO:0001894 tissue homeostasis
GO:0001944 vasculature development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002089 lens morphogenesis in camera-type eye
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003338 metanephros morphogenesis
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005916 fascia adherens
GO:0005923 bicellular tight junction
GO:0005938 cell cortex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007268 chemical synaptic transmission
GO:0007398 ectoderm development
GO:0007403 glial cell fate determination
GO:0007507 heart development
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009948 anterior/posterior axis specification
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0009987 cellular process
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010 Schwann cell proliferation
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016331 morphogenesis of embryonic epithelium
GO:0016342 catenin complex
GO:0016525 negative regulation of angiogenesis
GO:0016600 flotillin complex
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0021819 layer formation in cerebral cortex
GO:0022009 central nervous system vasculogenesis
GO:0022405 hair cycle process
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030217 T cell differentiation
GO:0030316 osteoclast differentiation
GO:0030324 lung development
GO:0030331 estrogen receptor binding
GO:0030539 male genitalia development
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030877 beta-catenin destruction complex
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0030997 regulation of centriole-centriole cohesion
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031253 cell projection membrane
GO:0031528 microvillus membrane
GO:0031641 regulation of myelination
GO:0031965 nuclear membrane
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032355 response to estradiol
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0033077 T cell differentiation in thymus
GO:0033234 negative regulation of protein sumoylation
GO:0034097 response to cytokine
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0034613 cellular protein localization
GO:0034750 Scrib-APC-beta-catenin complex
GO:0035050 embryonic heart tube development
GO:0035112 genitalia morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035255 ionotropic glutamate receptor binding
GO:0036023 embryonic skeletal limb joint morphogenesis
GO:0036520 astrocyte-dopaminergic neuron signaling
GO:0042127 regulation of cell population proliferation
GO:0042129 regulation of T cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0042734 presynaptic membrane
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043198 dendritic shaft
GO:0043296 apical junction complex
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0043588 skin development
GO:0043627 response to estrogen
GO:0044093 positive regulation of molecular function
GO:0044325 transmembrane transporter binding
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044338 canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
GO:0044877 protein-containing complex binding
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0045453 bone resorption
GO:0045595 regulation of cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045976 negative regulation of mitotic cell cycle, embryonic
GO:0046332 SMAD binding
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0048489 synaptic vesicle transport
GO:0048513 animal organ development
GO:0048538 thymus development
GO:0048568 embryonic organ development
GO:0048599 oocyte development
GO:0048617 embryonic foregut morphogenesis
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050768 negative regulation of neurogenesis
GO:0050808 synapse organization
GO:0050998 nitric-oxide synthase binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051145 smooth muscle cell differentiation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051884 regulation of timing of anagen
GO:0051973 positive regulation of telomerase activity
GO:0060038 cardiac muscle cell proliferation
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060439 trachea morphogenesis
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060479 lung cell differentiation
GO:0060484 lung-associated mesenchyme development
GO:0060485 mesenchyme development
GO:0060492 lung induction
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 hair follicle placode formation
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0060982 coronary artery morphogenesis
GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061154 endothelial tube morphogenesis
GO:0061198 fungiform papilla formation
GO:0061324 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0061549 sympathetic ganglion development
GO:0061550 cranial ganglion development
GO:0070369 beta-catenin-TCF7L2 complex
GO:0070411 I-SMAD binding
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071681 cellular response to indole-3-methanol
GO:0071944 cell periphery
GO:0072033 renal vesicle formation
GO:0072053 renal inner medulla development
GO:0072054 renal outer medulla development
GO:0072079 nephron tubule formation
GO:0072132 mesenchyme morphogenesis
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0090279 regulation of calcium ion import
GO:0097091 synaptic vesicle clustering
GO:0097718 disordered domain specific binding
GO:0098609 cell-cell adhesion
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098831 presynaptic active zone cytoplasmic component
GO:0099092 postsynaptic density, intracellular component
GO:0140297 DNA-binding transcription factor binding
GO:1901215 negative regulation of neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1904796 regulation of core promoter binding
GO:1904798 positive regulation of core promoter binding
GO:1904888 cranial skeletal system development
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1990138 neuron projection extension
GO:1990226 histone methyltransferase binding
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990403 embryonic brain development
GO:1990791 dorsal root ganglion development
GO:1990907 beta-catenin-TCF complex
GO:1990909 Wnt signalosome
GO:2000008 regulation of protein localization to cell surface
GO:2000017 positive regulation of determination of dorsal identity
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000225 ArmadilloRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR013284 Beta-cateninFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
CTNB1_MOUSECTNA1_MOUSEBioGRID, mbinfo, MINT10882138 12695331 17113272 32325033 9264463 details
CTNB1_MOUSEFER_HUMANMINT12640114 details
CTNB1_MOUSEFYN_HUMANMINT12640114 details
CTNB1_MOUSESRC_HUMANMINT12640114 details
CTNB1_MOUSEYES_HUMANMINT12640114 details
CTNB1_MOUSECNBP1_MOUSEBioGRID, MINT10898789 12874278 details
CTNB1_MOUSEP85A_MOUSEBioGRID, IntAct15102471 32325033 details
CTNB1_MOUSEMP2K5_MOUSEIntAct15102471 details
CTNB1_MOUSEPROP1_MOUSEBioGRID, IntAct16678101 details
CTNB1_MOUSECADH1_MOUSEBioGRID, DIP, IntAct11348595 11953314 12695331 12874278 14691142 15057752 16293619 16368433 19726720 21730140 23444350 25873176 details
CTNB1_MOUSELEF1_MOUSEBioGRID, IntAct16293619 16309666 17445771 18202148 24748645 details
CTNB1_MOUSECNBP1_HUMANBioGRID, IntAct12408825 16293619 details
CTNB1_MOUSEAPC_HUMANBioGRID, IntAct15327768 16293619 29045831 details
CTNB1_MOUSEAXIN1_HUMANBioGRID, IntAct12417018 16293619 details
CTNB1_MOUSETX1B3_MOUSEBioGRID, IntAct12874278 details
CTNB1_MOUSEBCL9_HUMANBioGRID, IntAct17113272 details
CTNB1_MOUSEBCL9L_HUMANBioGRID, IntAct17113272 details
CTNB1_MOUSECARM1_MOUSEMINT17882261 details
CTNB1_MOUSEMK09_HUMANIntAct18423204 details
CTNB1_MOUSETF7L2_HUMANBioGRID, IntAct12417018 22014570 details
CTNB1_MOUSEAXIN1_MOUSEBioGRID, IntAct, UniProt10318824 12805222 17053159 18316368 21242974 22682247 24976009 25873176 details
CTNB1_MOUSEGSK3B_MOUSEbhf-ucl, BioGRID10318824 12874278 15327768 19107203 32325033 details
CTNB1_MOUSEGSK3B_HUMANbhf-ucl, BioGRID, IntAct10481074 12417018 12421363 details
CTNB1_MOUSEAXIN2_MOUSEBioGRID, IntAct25873176 9554852 details
CTNB1_MOUSEITF2_MOUSEBioGRID, DIP12874278 15578569 16007074 21103407 details
CTNB1_MOUSESET1A_HUMANDIP22723415 details
CTNB1_MOUSERHG32_MOUSEBioGRID12531901 details
CTNB1_MOUSECTNB1_MOUSEBioGRID20211142 details
CTNB1_MOUSEKC1E_MOUSEBioGRID12417018 15327768 17053159 details
CTNB1_MOUSEPAX3_MOUSEBioGRID20006729 details
CTNB1_MOUSEHMGB2_MOUSEBioGRID19805379 details
CTNB1_MOUSETRAF4_HUMANBioGRID16969126 details
CTNB1_MOUSEFBW1A_HUMANBioGRID12417018 details
CTNB1_MOUSECASP3_MOUSEBioGRID18723680 details
CTNB1_MOUSECBP_HUMANBioGRID11973335 details
CTNB1_MOUSEEP300_HUMANBioGRID11973335 details
CTNB1_MOUSECTNA1_HUMANMINT12640114 details
CTNB1_MOUSETF7L2_MOUSEBioGRID, MINT10898789 17053159 19503085 19805521 19816403 details
CTNB1_MOUSENMDE2_MOUSEBioGRID, IntAct10862698 16635246 details
CTNB1_MOUSECADH5_MOUSEMINT18337748 details
CTNB1_MOUSEHD_MOUSEMINT20531388 details
CTNB1_MOUSECBP_MOUSEIntAct21751375 23273993 details
CTNB1_MOUSEFOXM1_MOUSEIntAct22014570 details
CTNB1_MOUSEDACT2_MOUSEUniProt21718540 details
CTNB1_MOUSEDACT3_MOUSEUniProt21718540 details
CTNB1_MOUSEYAP1_HUMANIntAct23245941 details
CTNB1_MOUSETBX5_HUMANIntAct23245941 details
CTNB1_MOUSETF65_MOUSEBioGRID, IntAct17445771 23273993 details
CTNB1_MOUSERPGF2_MOUSEUniProt10873669 details
CTNB1_MOUSEPTH1R_MOUSEIntAct23124878 details
CTNB1_MOUSERARA_MOUSEIntAct24074870 details
CTNB1_MOUSEFBW1A_MOUSEIntAct25873176 details
CTNB1_MOUSEPSN1_HUMANBioGRID, IntAct12070348 27036734 details
CTNB1_MOUSETERT_MOUSEDIP19571879 details
CTNB1_MOUSEAF10_MOUSEDIP21103407 details
CTNB1_MOUSEKLF4_MOUSEDIP22723415 details
CTNB1_MOUSEASH2L_HUMANDIP22723415 details
CTNB1_MOUSECTNA3_HUMANIntAct23136403 details
CTNB1_MOUSESHAN3_MOUSEMINT29531362 details
CTNB1_MOUSEP85A_HUMANBioGRID10477752 details
CTNB1_MOUSEPTPRF_MOUSEBioGRID8830779 details
CTNB1_MOUSEPPAC_MOUSEBioGRID12438242 32325033 details
CTNB1_MOUSEMUC1_HUMANBioGRID15221004 details
CTNB1_MOUSECAD15_HUMANBioGRID9545347 details
CTNB1_MOUSESOX2_MOUSEBioGRID15781477 details
CTNB1_MOUSEJUN_MOUSEBioGRID16007074 details
CTNB1_MOUSESMCA4_MOUSEBioGRID15525990 details
CTNB1_MOUSEMERL_MOUSEBioGRID12695331 details
CTNB1_MOUSECADH2_MOUSEBioGRID12695331 15834408 32325033 details
CTNB1_MOUSECTND1_MOUSEBioGRID12695331 15834408 32325033 details
CTNB1_MOUSEPTPRQ_MOUSEBioGRID16973135 details
CTNB1_MOUSEPCP2_MOUSEBioGRID16973135 details
CTNB1_MOUSEKIFA3_MOUSEBioGRID15834408 details
CTNB1_MOUSEKIF3B_MOUSEBioGRID15834408 details
CTNB1_MOUSEPIN1_MOUSEBioGRID19995909 details
CTNB1_MOUSEDCX_MOUSEBioGRID15607950 details
CTNB1_MOUSEUSP9X_MOUSEBioGRID15607950 details
CTNB1_MOUSECSN2_MOUSEBioGRID19576224 details
CTNB1_MOUSETF7L1_MOUSEBioGRID18202148 details
CTNB1_MOUSEESR1_MOUSEBioGRID18202148 details
CTNB1_MOUSEPO5F1_MOUSEBioGRID22083510 23444350 details
CTNB1_MOUSECUL4A_MOUSEBioGRID17954973 details
CTNB1_MOUSENUMB_MOUSEBioGRID17589506 details
CTNB1_MOUSENANOG_MOUSEBioGRID23444350 details
CTNB1_MOUSESTF1_MOUSEBioGRID12861022 details
CTNB1_MOUSEFOXO3_MOUSEBioGRID29717119 details
CTNB1_MOUSEITF2_HUMANBioGRID15578569 details
CTNB1_MOUSESOX17_MOUSEBioGRID31823782 details