Entity Details

Primary name MTF2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ02395
EntryNameMTF2_MOUSE
FullNameMetal-response element-binding transcription factor 2
TaxID10090
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesMtf2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0007379 segment specification
GO:0019827 stem cell population maintenance
GO:0035064 methylated histone binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048863 stem cell differentiation
GO:0061086 negative regulation of histone H3-K27 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002999 Tudor domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR025894 Polycomb-like MTF2 factor 2, C-terminal domainDomainDomain
IPR040477 Lysine-specific demethylase 4, Tudor domainDomainDomain
IPR042014 MTF2, PHD domain 1DomainDomain
IPR042015 MTF2, PHD domain 2DomainDomain

Diseases

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