Entity Details

Primary name TIE2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ02858
EntryNameTIE2_MOUSE
FullNameAngiopoietin-1 receptor
TaxID10090
Evidenceevidence at protein level
Length1122
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesTek

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007160 cell-matrix adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007507 heart development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016525 negative regulation of angiogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0030097 hemopoiesis
GO:0030334 regulation of cell migration
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032526 response to retinoic acid
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034451 centriolar satellite
GO:0038023 signaling receptor activity
GO:0042307 positive regulation of protein import into nucleus
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045121 membrane raft
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0046777 protein autophosphorylation
GO:0048014 Tie signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060347 heart trabecula formation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072012 glomerulus vasculature development
GO:0098609 cell-cell adhesion
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1902533 positive regulation of intracellular signal transduction
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminalDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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