Entity Details

Primary name EPHA2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ03145
EntryNameEPHA2_MOUSE
FullNameEphrin type-A receptor 2
TaxID10090
Evidenceevidence at protein level
Length977
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesEpha2

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001818 negative regulation of cytokine production
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 cell surface
GO:0010591 regulation of lamellipodium assembly
GO:0014028 notochord formation
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0019838 growth factor binding
GO:0021915 neural tube development
GO:0030027 lamellipodium
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030316 osteoclast differentiation
GO:0031256 leading edge membrane
GO:0031258 lamellipodium membrane
GO:0032587 ruffle membrane
GO:0032682 negative regulation of chemokine production
GO:0033598 mammary gland epithelial cell proliferation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0036342 post-anal tail morphogenesis
GO:0043005 neuron projection
GO:0043235 receptor complex
GO:0043491 protein kinase B signaling
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0045765 regulation of angiogenesis
GO:0046058 cAMP metabolic process
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
GO:0048320 axial mesoderm formation
GO:0048514 blood vessel morphogenesis
GO:0048570 notochord morphogenesis
GO:0048870 cell motility
GO:0050830 defense response to Gram-positive bacterium
GO:0051898 negative regulation of protein kinase B signaling
GO:0060035 notochord cell development
GO:0060326 cell chemotaxis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0070160 tight junction
GO:0070309 lens fiber cell morphogenesis
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0072659 protein localization to plasma membrane
GO:0090630 activation of GTPase activity
GO:1901491 negative regulation of lymphangiogenesis
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903348 positive regulation of bicellular tight junction assembly
GO:1904238 pericyte cell differentiation

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034263 Ephrin type-A receptor 2, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
EPHA2_MOUSEEPHA4_MOUSEMINT16977320 details
EPHA2_MOUSERET_MOUSEIntAct22304922 details