Entity Details

Primary name TF65_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ04207
EntryNameTF65_MOUSE
FullNameTranscription factor p65
TaxID10090
Evidenceevidence at protein level
Length549
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesRela

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001889 liver development
GO:0001942 hair follicle development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006117 acetaldehyde metabolic process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009617 response to bacterium
GO:0009887 animal organ morphogenesis
GO:0010033 response to organic substance
GO:0010224 response to UV-B
GO:0014040 positive regulation of Schwann cell differentiation
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032495 response to muramyl dipeptide
GO:0032570 response to progesterone
GO:0032735 positive regulation of interleukin-12 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032868 response to insulin
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033234 negative regulation of protein sumoylation
GO:0033590 response to cobalamin
GO:0034097 response to cytokine
GO:0035525 NF-kappaB p50/p65 complex
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0035994 response to muscle stretch
GO:0038061 NIK/NF-kappaB signaling
GO:0042177 negative regulation of protein catabolic process
GO:0042277 peptide binding
GO:0042301 phosphate ion binding
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042805 actinin binding
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0043278 response to morphine
GO:0043565 sequence-specific DNA binding
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0047485 protein N-terminus binding
GO:0050727 regulation of inflammatory response
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051059 NF-kappaB binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051591 response to cAMP
GO:0070301 cellular response to hydrogen peroxide
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071159 NF-kappaB complex
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071316 cellular response to nicotine
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071532 ankyrin repeat binding
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1902004 positive regulation of amyloid-beta formation
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904385 cellular response to angiotensin
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:2000630 positive regulation of miRNA metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000451 NF-kappa-B/DorsalFamilyFamily
IPR002909 IPT domainDomainDomain
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR011539 Rel homology domain (RHD), DNA-binding domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR030492 Rel homology domain, conserved siteSiteConserved site
IPR030495 Transcription factor RelA (p65)FamilyFamily
IPR032397 Rel homology dimerisation domainDomainDomain
IPR033926 NFkappaB IPT domainDomainDomain
IPR037059 Rel homology domain (RHD), DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
TF65_MOUSENFKB1_MOUSEBioGRID, DIP, I2D, IntAct, MINT11970949 19887633 20211142 20740013 21056038 21220295 21706061 23538752 9556555 details
TF65_MOUSEIKBB_MOUSEDIP, IntAct12686541 15102471 20740013 details
TF65_MOUSEIKBA_MOUSEBioGRID, DIP, I2D, InnateDB, IntAct, MINT15102471 16163708 16928772 17254973 18401342 20634424 20740013 21098220 21706061 23086447 23850221 details
TF65_MOUSENFKB2_MOUSEBioGRID, IntAct17254973 18362156 20211142 details
TF65_MOUSECBP_MOUSEDIP, IntAct24019758 9556555 details
TF65_MOUSESETD6_HUMANInnateDB21131967 details
TF65_MOUSESETD7_HUMANInnateDB21131967 details
TF65_MOUSEEHMT1_HUMANInnateDB21131967 details
TF65_MOUSEKPCZ_HUMANInnateDB21131967 details
TF65_MOUSEMED17_MOUSEDIP19338389 details
TF65_MOUSETF65_MOUSEBioGRID, DIP19338389 19887633 20211142 details
TF65_MOUSEEP300_MOUSEBioGRID, DIP12672795 20211142 23999430 24019758 details
TF65_MOUSEDNMT1_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSEPANKY_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSESRBP1_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSEZDH13_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSEZMY11_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSEANKR7_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSECXXC1_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSECERS2_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSEBRPF1_MOUSEBioGRID, IntAct20211142 details
TF65_MOUSEPIAS3_MOUSEBioGRID20211142 details
TF65_MOUSENANOG_MOUSEBioGRID18223644 details
TF65_MOUSEHDAC1_MOUSEBioGRID, IntAct11931769 details
TF65_MOUSENR4A2_MOUSEIntAct19345186 details
TF65_MOUSENOS2_MOUSEDIP, IntAct19345186 21464294 details
TF65_MOUSEUBB_MOUSEMINT19270718 details
TF65_MOUSEUBC_MOUSEMINT19270718 details
TF65_MOUSERS27A_MOUSEMINT19270718 details
TF65_MOUSERL40_MOUSEMINT19270718 details
TF65_MOUSEGFI1_MOUSEUniProt20547752 details
TF65_MOUSENR0B2_MOUSEBioGRID, InnateDB21725320 details
TF65_MOUSENR0B2_HUMANInnateDB21725320 details
TF65_MOUSECTNB1_MOUSEBioGRID, IntAct17445771 23273993 details
TF65_MOUSEKAT2A_MOUSEMINT25024434 details
TF65_MOUSEPIAS4_MOUSEBioGRID, DIP17606919 20054338 details
TF65_MOUSEMED16_MOUSEDIP19338389 details
TF65_MOUSENR4A1_MOUSEDIP25822914 details
TF65_MOUSEHDAC6_MOUSEBioGRID12372765 details
TF65_MOUSESIR1_MOUSEBioGRID21454709 details
TF65_MOUSESP1_MOUSEBioGRID21262356 details
TF65_MOUSEJUN_MOUSEBioGRID21262356 details
TF65_MOUSEHSF1_MOUSEBioGRID17766920 details
TF65_MOUSEFM1AA_MOUSEBioGRID18270204 details
TF65_MOUSEPPARG_MOUSEBioGRID23250430 details