Entity Details

Primary name TOP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ04750
EntryNameTOP1_MOUSE
FullNameDNA topoisomerase 1
TaxID10090
Evidenceevidence at protein level
Length767
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesTop1

GO terms

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GOName
GO:0000228 nuclear chromosome
GO:0000932 P-body
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001650 fibrillar center
GO:0001651 dense fibrillar component
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0006338 chromatin remodeling
GO:0007059 chromosome segregation
GO:0009303 rRNA transcription
GO:0018105 peptidyl-serine phosphorylation
GO:0019904 protein domain specific binding
GO:0031490 chromatin DNA binding
GO:0032922 circadian regulation of gene expression
GO:0032993 protein-DNA complex
GO:0040016 embryonic cleavage
GO:0042493 response to drug
GO:0043204 perikaryon
GO:0044877 protein-containing complex binding
GO:0097100 supercoiled DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001631 DNA topoisomerase IFamilyFamily
IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-typeDomainDomain
IPR011010 DNA breaking-rejoining enzyme, catalytic coreFamilyHomologous superfamily
IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2FamilyHomologous superfamily
IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1FamilyHomologous superfamily
IPR013499 DNA topoisomerase I, eukaryotic-typeDomainDomain
IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-typeDomainDomain
IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-typeFamilyHomologous superfamily
IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomainFamilyHomologous superfamily
IPR018521 DNA topoisomerase I, active siteSiteActive site
IPR025834 Topoisomerase I C-terminal domainDomainDomain
IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TOP1_MOUSEPRAF1_MOUSEIntAct30925931 details
TOP1_MOUSETAL1_MOUSEMINT16407974 details