Entity Details

Primary name PGH2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ05769
EntryNamePGH2_MOUSE
FullNameProstaglandin G/H synthase 2
TaxID10090
Evidenceevidence at protein level
Length604
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPtgs2

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0001525 angiogenesis
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007612 learning
GO:0007613 memory
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009750 response to fructose
GO:0010042 response to manganese ion
GO:0010226 response to lithium ion
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010942 positive regulation of cell death
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019233 sensory perception of pain
GO:0019371 cyclooxygenase pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0030216 keratinocyte differentiation
GO:0030282 bone mineralization
GO:0030728 ovulation
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0031915 positive regulation of synaptic plasticity
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033280 response to vitamin D
GO:0034097 response to cytokine
GO:0034605 cellular response to heat
GO:0034612 response to tumor necrosis factor
GO:0034644 cellular response to UV
GO:0035633 maintenance of blood-brain barrier
GO:0042127 regulation of cell population proliferation
GO:0042307 positive regulation of protein import into nucleus
GO:0042493 response to drug
GO:0042633 hair cycle
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045786 negative regulation of cell cycle
GO:0045907 positive regulation of vasoconstriction
GO:0045986 negative regulation of smooth muscle contraction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046697 decidualization
GO:0046872 metal ion binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050873 brown fat cell differentiation
GO:0051384 response to glucocorticoid
GO:0051926 negative regulation of calcium ion transport
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0070542 response to fatty acid
GO:0071260 cellular response to mechanical stimulus
GO:0071284 cellular response to lead ion
GO:0071318 cellular response to ATP
GO:0071471 cellular response to non-ionic osmotic stress
GO:0071498 cellular response to fluid shear stress
GO:0071636 positive regulation of transforming growth factor beta production
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 positive regulation of fibroblast growth factor production
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090362 positive regulation of platelet-derived growth factor production
GO:0150077 regulation of neuroinflammatory response
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1990776 response to angiotensin

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane
Nucleus inner membrane
Nucleus outer membrane

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR010255 Haem peroxidase superfamilyFamilyHomologous superfamily
IPR019791 Haem peroxidase, animal-typeFamilyFamily
IPR029576 Prostaglandin G/H synthase 2FamilyFamily
IPR037120 Haem peroxidase domain superfamily, animal typeFamilyHomologous superfamily

Diseases

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Interactions

4 interactions