Entity Details

Primary name PTN2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ06180
EntryNamePTN2_MOUSE
FullNameTyrosine-protein phosphatase non-receptor type 2
TaxID10090
Evidenceevidence at protein level
Length406
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPtpn2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 negative regulation of lipid storage
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030971 receptor tyrosine kinase binding
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0045650 negative regulation of macrophage differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050922 negative regulation of chemotaxis
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0097677 STAT family protein binding
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 negative regulation of positive thymic T cell selection
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903899 positive regulation of PERK-mediated unfolded protein response
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum-Golgi intermediate compartment
Nucleus

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

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Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink