Entity Details

Primary name CLUS_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ06890
EntryNameCLUS_MOUSE
FullNameClusterin
TaxID10090
Evidenceevidence at protein level
Length448
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesClu

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0002434 immune complex clearance
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0016235 aggresome
GO:0017038 protein import
GO:0030426 growth cone
GO:0031018 endocrine pancreas development
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032286 central nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034366 spherical high-density lipoprotein particle
GO:0042127 regulation of cell population proliferation
GO:0042583 chromaffin granule
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0047485 protein N-terminus binding
GO:0048156 tau protein binding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0048812 neuron projection morphogenesis
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051131 chaperone-mediated protein complex assembly
GO:0051787 misfolded protein binding
GO:0051788 response to misfolded protein
GO:0060548 negative regulation of cell death
GO:0061077 chaperone-mediated protein folding
GO:0061518 microglial cell proliferation
GO:0071944 cell periphery
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097418 neurofibrillary tangle
GO:0097440 apical dendrite
GO:0099020 perinuclear endoplasmic reticulum lumen
GO:1900221 regulation of amyloid-beta clearance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of amyloid-beta formation
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 negative regulation of amyloid-beta formation
GO:1902847 regulation of neuronal signal transduction
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1905892 negative regulation of cellular response to thapsigargin
GO:1905895 negative regulation of cellular response to tunicamycin
GO:1905907 negative regulation of amyloid fibril formation
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum
Microsome
Mitochondrion
Mitochondrion membrane
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000753 Clusterin-likeFamilyFamily
IPR016014 Clusterin, N-terminalDomainDomain
IPR016015 Clusterin, C-terminalDomainDomain
IPR016016 ClusterinFamilyFamily
IPR033986 Clusterin, conserved siteSiteConserved site

Diseases

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