Entity Details

Primary name SIAH2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ06986
EntryNameSIAH2_MOUSE
FullNameE3 ubiquitin-protein ligase SIAH2
TaxID10090
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated2004-04-26
DateModified2021-06-02

Ontological Relatives

GenesSiah2

GO terms

Show/Hide Table
GOName
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007275 multicellular organism development
GO:0008270 zinc ion binding
GO:0031396 regulation of protein ubiquitination
GO:0031624 ubiquitin conjugating enzyme binding
GO:0042752 regulation of circadian rhythm
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044257 cellular protein catabolic process
GO:0048511 rhythmic process
GO:0061630 ubiquitin protein ligase activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR004162 E3 ubiquitin-protein ligase SINA-like, animalFamilyFamily
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR013010 Zinc finger, SIAH-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR018121 Seven-in-absentia protein, TRAF-like domainDomainDomain

Diseases

Show/Hide Table