Entity Details

Primary name PLK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ07832
EntryNamePLK1_MOUSE
FullNameSerine/threonine-protein kinase PLK1
TaxID10090
Evidenceevidence at protein level
Length603
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesPlk1

GO terms

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GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0000287 magnesium ion binding
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000779 condensed chromosome, centromeric region
GO:0000785 chromatin
GO:0000795 synaptonemal complex
GO:0000922 spindle pole
GO:0001578 microtubule bundle formation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005876 spindle microtubule
GO:0006468 protein phosphorylation
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007098 centrosome cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008017 microtubule binding
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010997 anaphase-promoting complex binding
GO:0015630 microtubule cytoskeleton
GO:0016321 female meiosis chromosome segregation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0030496 midbody
GO:0031648 protein destabilization
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032465 regulation of cytokinesis
GO:0033365 protein localization to organelle
GO:0034451 centriolar satellite
GO:0040038 polar body extrusion after meiotic divisions
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043393 regulation of protein binding
GO:0045143 homologous chromosome segregation
GO:0045184 establishment of protein localization
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862 positive regulation of proteolysis
GO:0051081 nuclear membrane disassembly
GO:0051233 spindle midzone
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0070194 synaptonemal complex disassembly
GO:0071168 protein localization to chromatin
GO:0090435 protein localization to nuclear envelope
GO:0097431 mitotic spindle pole
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901673 regulation of mitotic spindle assembly
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1904776 regulation of protein localization to cell cortex

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000959 POLO box domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033695 Second polo-box domainDomainDomain
IPR033701 First polo-box domainDomainDomain
IPR033702 Polo-like kinase 1, catalytic domainDomainDomain
IPR036947 POLO box domain superfamilyFamilyHomologous superfamily

Diseases

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