Entity Details

Primary name GATA4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ08369
EntryNameGATA4_MOUSE
FullNameTranscription factor GATA-4
TaxID10090
Evidenceevidence at protein level
Length441
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesGata4

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001216 DNA-binding transcription activator activity
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0001934 positive regulation of protein phosphorylation
GO:0001947 heart looping
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003190 atrioventricular valve formation
GO:0003192 mitral valve formation
GO:0003195 tricuspid valve formation
GO:0003197 endocardial cushion development
GO:0003215 cardiac right ventricle morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003289 atrial septum primum morphogenesis
GO:0003290 atrial septum secundum morphogenesis
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008584 male gonad development
GO:0009612 response to mechanical stimulus
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016604 nuclear body
GO:0019901 protein kinase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030513 positive regulation of BMP signaling pathway
GO:0032526 response to retinoic acid
GO:0035050 embryonic heart tube development
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0035239 tube morphogenesis
GO:0035914 skeletal muscle cell differentiation
GO:0036302 atrioventricular canal development
GO:0042060 wound healing
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043627 response to estrogen
GO:0045165 cell fate commitment
GO:0045766 positive regulation of angiogenesis
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048557 embryonic digestive tract morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048617 embryonic foregut morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0051525 NFAT protein binding
GO:0051891 positive regulation of cardioblast differentiation
GO:0051896 regulation of protein kinase B signaling
GO:0055007 cardiac muscle cell differentiation
GO:0060008 Sertoli cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060290 transdifferentiation
GO:0060395 SMAD protein signal transduction
GO:0060413 atrial septum morphogenesis
GO:0060425 lung morphogenesis
GO:0060464 lung lobe formation
GO:0060540 diaphragm morphogenesis
GO:0060575 intestinal epithelial cell differentiation
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0061026 cardiac muscle tissue regeneration
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070410 co-SMAD binding
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0072148 epithelial cell fate commitment
GO:0072520 seminiferous tubule development
GO:0086004 regulation of cardiac muscle cell contraction
GO:0090575 RNA polymerase II transcription regulator complex
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1905204 negative regulation of connective tissue replacement
GO:1990837 sequence-specific double-stranded DNA binding
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000679 Zinc finger, GATA-typeDomainDomain
IPR008013 GATA-type transcription activator, N-terminalDomainDomain
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR016375 Transcription factor GATA-4/5/6FamilyFamily
IPR039355 Transcription factor GATAFamilyFamily

Diseases

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