Entity Details

Primary name RUNX2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ08775
EntryNameRUNX2_MOUSE
FullNameRunt-related transcription factor 2
TaxID10090
Evidenceevidence at protein level
Length607
SequenceStatuscomplete
DateCreated2001-11-02
DateModified2021-06-02

Ontological Relatives

GenesRunx2

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001958 endochondral ossification
GO:0002051 osteoblast fate commitment
GO:0002062 chondrocyte differentiation
GO:0002063 chondrocyte development
GO:0002076 osteoblast development
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0019904 protein domain specific binding
GO:0030097 hemopoiesis
GO:0030182 neuron differentiation
GO:0030217 T cell differentiation
GO:0030278 regulation of ossification
GO:0030509 BMP signaling pathway
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032991 protein-containing complex
GO:0035115 embryonic forelimb morphogenesis
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042826 histone deacetylase binding
GO:0043425 bHLH transcription factor binding
GO:0045595 regulation of cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048469 cell maturation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048863 stem cell differentiation
GO:0071773 cellular response to BMP stimulus
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000040 Acute myeloid leukemia 1 protein (AML1)/RuntFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013524 Runt domainDomainDomain
IPR013711 Runx, C-terminal domainDomainDomain
IPR027384 Runx, central domain superfamilyFamilyHomologous superfamily

Diseases

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