Entity Details

Primary name MITF_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ08874
EntryNameMITF_MOUSE
FullNameMicrophthalmia-associated transcription factor
TaxID10090
Evidenceevidence at protein level
Length526
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesMitf

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0030154 cell differentiation
GO:0030316 osteoclast differentiation
GO:0030318 melanocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0032991 protein-containing complex
GO:0042127 regulation of cell population proliferation
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0043473 pigmentation
GO:0043565 sequence-specific DNA binding
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165 cell fate commitment
GO:0045670 regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046849 bone remodeling
GO:0046983 protein dimerization activity
GO:0065003 protein-containing complex assembly
GO:0070888 E-box binding
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2001141 regulation of RNA biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR021802 MiT/TFE transcription factors, C-terminalDomainDomain
IPR030532 Microphthalmia-associated transcription factorFamilyFamily
IPR031867 MiT/TFE transcription factors, N-terminalDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions