Entity Details

Primary name RTEL1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ0VGM9
EntryNameRTEL1_MOUSE
FullNameRegulator of telomere elongation helicase 1
TaxID10090
Evidenceevidence at protein level
Length1203
SequenceStatuscomplete
DateCreated2009-05-05
DateModified2021-06-02

Ontological Relatives

GenesRtel1

GO terms

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GOName
GO:0000723 telomere maintenance
GO:0000732 strand displacement
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0006281 DNA repair
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0031297 replication fork processing
GO:0032206 positive regulation of telomere maintenance
GO:0032508 DNA duplex unwinding
GO:0043247 telomere maintenance in response to DNA damage
GO:0045910 negative regulation of DNA recombination
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0061820 telomeric D-loop disassembly
GO:0070182 DNA polymerase binding
GO:0090657 telomeric loop disassembly
GO:1902990 mitotic telomere maintenance via semi-conservative replication
GO:1904355 positive regulation of telomere capping
GO:1904358 positive regulation of telomere maintenance via telomere lengthening
GO:1904430 negative regulation of t-circle formation
GO:1904506 negative regulation of telomere maintenance in response to DNA damage
GO:1904535 positive regulation of telomeric loop disassembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR006554 Helicase-like, DEXD box c2 typeDomainDomain
IPR006555 ATP-dependent helicase, C-terminalDomainDomain
IPR010614 DEAD2DomainDomain
IPR013020 ATP-dependent helicase Rad3/Chl1-likeFamilyFamily
IPR014013 Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-typeDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030845 Regulator of telomere elongation helicase 1FamilyFamily

Diseases

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Interactions

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