Entity Details

Primary name GRM2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ14BI2
EntryNameGRM2_MOUSE
FullNameMetabotropic glutamate receptor 2
TaxID10090
Evidenceevidence at protein level
Length872
SequenceStatuscomplete
DateCreated2007-10-02
DateModified2021-06-02

Ontological Relatives

GenesGrm2

GO terms

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GOName
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0001641 group II metabotropic glutamate receptor activity
GO:0005246 calcium channel regulator activity
GO:0005887 integral component of plasma membrane
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0010467 gene expression
GO:0014047 glutamate secretion
GO:0014048 regulation of glutamate secretion
GO:0014059 regulation of dopamine secretion
GO:0030424 axon
GO:0030425 dendrite
GO:0035095 behavioral response to nicotine
GO:0042220 response to cocaine
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0051896 regulation of protein kinase B signaling
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0090461 glutamate homeostasis
GO:0097110 scaffold protein binding
GO:0097449 astrocyte projection
GO:0099055 integral component of postsynaptic membrane
GO:2001023 regulation of response to drug

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000162 GPCR, family 3, metabotropic glutamate receptorFamilyFamily
IPR000337 GPCR, family 3FamilyFamily
IPR001458 GPCR, family 3, metabotropic glutamate receptor 2FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011500 GPCR, family 3, nine cysteines domainDomainDomain
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR038550 GPCR, family 3, nine cysteines domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
GRM2_MOUSERANB9_MOUSEMINT18555800 details
GRM2_MOUSE5HT2A_MOUSEIntAct22118459 details