Entity Details

Primary name SMCA4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ3TKT4
EntryNameSMCA4_MOUSE
FullNameTranscription activator BRG1
TaxID10090
Evidenceevidence at protein level
Length1613
SequenceStatuscomplete
DateCreated2010-02-09
DateModified2021-06-02

Ontological Relatives

GenesSmarca4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000902 cell morphogenesis
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001188 RNA polymerase I preinitiation complex assembly
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001832 blastocyst growth
GO:0001835 blastocyst hatching
GO:0001889 liver development
GO:0002039 p53 binding
GO:0003151 outflow tract morphogenesis
GO:0003281 ventricular septum development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005726 perichromatin fibrils
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006346 DNA methylation-dependent heterochromatin assembly
GO:0007399 nervous system development
GO:0007403 glial cell fate determination
GO:0007507 heart development
GO:0008094 ATPase, acting on DNA
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010424 DNA methylation on cytosine within a CG sequence
GO:0010467 gene expression
GO:0016514 SWI/SNF complex
GO:0016887 ATP hydrolysis activity
GO:0019827 stem cell population maintenance
GO:0022008 neurogenesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030198 extracellular matrix organization
GO:0030216 keratinocyte differentiation
GO:0030308 negative regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0030957 Tat protein binding
GO:0035116 embryonic hindlimb morphogenesis
GO:0035887 aortic smooth muscle cell differentiation
GO:0035904 aorta development
GO:0043044 ATP-dependent chromatin remodeling
GO:0043066 negative regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043923 positive regulation by host of viral transcription
GO:0043966 histone H3 acetylation
GO:0044877 protein-containing complex binding
GO:0045597 positive regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0047485 protein N-terminus binding
GO:0048562 embryonic organ morphogenesis
GO:0048730 epidermis morphogenesis
GO:0050681 androgen receptor binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060318 definitive erythrocyte differentiation
GO:0060347 heart trabecula formation
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060976 coronary vasculature development
GO:0061626 pharyngeal arch artery morphogenesis
GO:0070182 DNA polymerase binding
GO:0070307 lens fiber cell development
GO:0070577 lysine-acetylated histone binding
GO:0070615 nucleosome-dependent ATPase activity
GO:0071564 npBAF complex
GO:0071565 nBAF complex
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1902661 positive regulation of glucose mediated signaling pathway
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR001487 BromodomainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR006576 BRK domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014012 Helicase/SANT-associated domainDomainDomain
IPR014978 Glutamine-Leucine-Glutamine, QLQDomainDomain
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029295 Snf2, ATP coupling domainDomainDomain
IPR030100 SWI/SNF complex subunit BRG1FamilyFamily
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR037259 BRK domain superfamilyFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
SMCA4_MOUSERB_HUMANBioGRID, IntAct12434308 7923370 details
SMCA4_MOUSERBL1_HUMANIntAct12434308 details
SMCA4_MOUSERBL2_HUMANIntAct12434308 details
SMCA4_MOUSERB_MOUSEBioGRID, IntAct7923370 details
SMCA4_MOUSESMRC1_MOUSEBioGRID, DIP, IntAct, MINT12368262 17255092 19279220 23540691 23698369 24421395 32640256 details
SMCA4_MOUSEADDA_MOUSEBioGRID17074803 details
SMCA4_MOUSEETS2_MOUSEBioGRID12637547 details
SMCA4_MOUSEMEF2A_HUMANMINT16424906 details
SMCA4_MOUSEMYOG_MOUSEMINT16424906 details
SMCA4_MOUSEANM5_MOUSEBioGRID, IntAct17043109 20951943 details
SMCA4_MOUSESMRC2_MOUSEBioGRID, MINT12368262 19279220 21552207 details
SMCA4_MOUSESMCE1_MOUSEBioGRID, DIP, IntAct, MINT12368262 19279220 19781646 21552207 23540691 23698369 details
SMCA4_MOUSEDDX5_MOUSEUniProt17011493 details
SMCA4_MOUSESMRD3_MOUSEBioGRID, MINT19279220 22068056 details
SMCA4_MOUSEOLIG2_MOUSEIntAct23332759 details
SMCA4_MOUSESNF5_MOUSEBioGRID, DIP, IntAct12368262 19279220 23540691 23698369 32640256 details
SMCA4_MOUSEARI1A_MOUSEBioGRID, DIP, IntAct12368262 17255939 19279220 23540691 23698369 32640256 details
SMCA4_MOUSEARI1B_MOUSEBioGRID, DIP, IntAct11988099 17255939 19279220 23540691 23698369 details
SMCA4_MOUSEACL6A_MOUSEBioGRID, IntAct19279220 23540691 details
SMCA4_MOUSEHNRPU_MOUSEIntAct22162999 details
SMCA4_MOUSEZMIZ1_MOUSEUniProt26163108 details
SMCA4_MOUSENOTC1_MOUSEDIP17210915 details
SMCA4_MOUSEGATA1_MOUSEDIP19171905 details
SMCA4_MOUSETERT_MOUSEDIP19571879 details
SMCA4_MOUSEHDAC1_MOUSEDIP20596014 details
SMCA4_MOUSEPARP1_MOUSEDIP20596014 details
SMCA4_MOUSEHDAC2_MOUSEDIP20596014 details
SMCA4_MOUSEHDAC9_MOUSEDIP20596014 details
SMCA4_MOUSEHDAC3_MOUSEDIP20596014 details
SMCA4_MOUSETOP2A_MOUSEDIP23698369 details
SMCA4_MOUSESMRD1_MOUSEBioGRID, DIP19279220 23698369 details
SMCA4_MOUSEREQU_MOUSEBioGRID, DIP19279220 23698369 details
SMCA4_MOUSEMECP2_MOUSEMINT19602036 24270455 details
SMCA4_MOUSENR1H4_MOUSEBioGRID19805516 details
SMCA4_MOUSENKX21_MOUSEBioGRID19906647 details
SMCA4_MOUSENANOG_MOUSEBioGRID18454139 details
SMCA4_MOUSECREST_MOUSEBioGRID19279220 details
SMCA4_MOUSESFPQ_MOUSEBioGRID19279220 details
SMCA4_MOUSENUMA1_MOUSEBioGRID19279220 details
SMCA4_MOUSENONO_MOUSEBioGRID19279220 details
SMCA4_MOUSEMBB1A_MOUSEBioGRID19279220 details
SMCA4_MOUSESRRM2_MOUSEBioGRID19279220 details
SMCA4_MOUSEBRD9_MOUSEBioGRID19279220 32640256 details
SMCA4_MOUSEBRD7_MOUSEBioGRID19279220 details
SMCA4_MOUSEBCL7A_MOUSEBioGRID19279220 details
SMCA4_MOUSEBICRA_MOUSEBioGRID19279220 details
SMCA4_MOUSEACTG_MOUSEBioGRID19279220 details
SMCA4_MOUSEPHF10_MOUSEBioGRID19279220 32640256 details
SMCA4_MOUSEARID2_MOUSEBioGRID19279220 details
SMCA4_MOUSESMCA2_MOUSEBioGRID19279220 details
SMCA4_MOUSEACL6B_MOUSEBioGRID12368262 details
SMCA4_MOUSESMCA4_MOUSEBioGRID12368262 details
SMCA4_MOUSESMRD2_MOUSEBioGRID12368262 details
SMCA4_MOUSENF1_MOUSEBioGRID15999204 details
SMCA4_MOUSERPB1_MOUSEBioGRID15999204 details
SMCA4_MOUSETBX5_MOUSEBioGRID15525990 details
SMCA4_MOUSENKX25_MOUSEBioGRID15525990 details
SMCA4_MOUSEGATA4_MOUSEBioGRID15525990 details
SMCA4_MOUSECTNB1_MOUSEBioGRID15525990 details
SMCA4_MOUSEKDM4A_MOUSEBioGRID21445275 details
SMCA4_MOUSEKDM4B_MOUSEBioGRID21445275 details
SMCA4_MOUSEKDM4C_MOUSEBioGRID21445275 details
SMCA4_MOUSECDX2_MOUSEBioGRID20485553 details
SMCA4_MOUSESTAT6_MOUSEBioGRID21262765 details
SMCA4_MOUSETBX21_MOUSEBioGRID21095589 details
SMCA4_MOUSEKDM6B_MOUSEBioGRID21095589 details
SMCA4_MOUSEKDM6A_MOUSEBioGRID21095589 details
SMCA4_MOUSEKLF4_MOUSEBioGRID20305087 details
SMCA4_MOUSEMYC_MOUSEBioGRID20305087 details
SMCA4_MOUSEEYA1_MOUSEBioGRID22513373 details
SMCA4_MOUSESIX1_MOUSEBioGRID22513373 details
SMCA4_MOUSEP53_MOUSEBioGRID18303029 details
SMCA4_MOUSEMYSM1_MOUSEBioGRID22169041 details
SMCA4_MOUSEKS6A5_MOUSEBioGRID20129940 details
SMCA4_MOUSEFOXP3_MOUSEBioGRID22922362 details
SMCA4_MOUSELMBL2_MOUSEBioGRID22770845 details
SMCA4_MOUSEE2F1_MOUSEBioGRID23868976 details
SMCA4_MOUSEGLI3_MOUSEBioGRID21768360 details