Entity Details

Primary name CBLB_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ3TTA7
EntryNameCBLB_MOUSE
FullNameE3 ubiquitin-protein ligase CBL-B
TaxID10090
Evidenceevidence at protein level
Length982
SequenceStatuscomplete
DateCreated2006-02-07
DateModified2021-06-02

Ontological Relatives

GenesCblb

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002669 positive regulation of T cell anergy
GO:0005509 calcium ion binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0017124 SH3 domain binding
GO:0018193 peptidyl-amino acid modification
GO:0019901 protein kinase binding
GO:0030155 regulation of cell adhesion
GO:0030971 receptor tyrosine kinase binding
GO:0031398 positive regulation of protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0042110 T cell activation
GO:0043087 regulation of GTPase activity
GO:0043393 regulation of protein binding
GO:0045121 membrane raft
GO:0045732 positive regulation of protein catabolic process
GO:0046642 negative regulation of alpha-beta T cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003153 Adaptor protein Cbl, N-terminal helicalDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014741 Adaptor protein Cbl, EF hand-likeDomainDomain
IPR014742 Adaptor protein Cbl, SH2-like domainDomainDomain
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR024159 Adaptor protein Cbl, PTB domainDomainDomain
IPR024162 Adaptor protein CblFamilyFamily
IPR036537 Adaptor protein Cbl, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039520 E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclassDomainDomain

Diseases

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